Evaluation of the efficacy of intravenous lidocaine on chronic postoperative pain in patients requiring emergency abdominal surgery. Randomized, double-blind, controlled, multicenter study – LIDOC-POPEYE.
EU CTIS ID: 2025-523682-24-00
What this study is testing
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- -Patients aged 18 years or older and under 80 years
- -Emergency or semi-emergency abdominal surgery of the following types: -urological -gastrointestinal -gynecological
- -Open or laparoscopic surgery
- -Estimated duration of surgery ≥ 60 minutes
- Informed consent for competent patients. Consent from the designated representative, or emergency procedure, followed by obtaining the patient’s consent to continue treatment after surgery
You likely can't join if
- -Use of a regional anesthesia technique via epidural analgesia
- -Pregnancy or breastfeeding. Women of childbearing age will undergo a pregnancy test prior to enrollment. -Porphyria
- Porphyria
- Surgery in Connection with a Transplant
- - Contraindications to lidocaine: § Known hypersensitivity to lidocaine, excipients, or amide-type local anesthetics. § Complete heart block § Hypovolemia - Contraindications to treatment with 0.9% NaCl: § Hyperchloremia § Hypernatremia § Severe cases of fluid overload and water-sodium retention, particularly in cases of decompensated heart failure, decompensated liver failure (edematous-ascitic cirrhosis), preeclampsia/ eclampsia.
- - Patients under legal guardianship, conservatorship, or judicial protection.
See the full eligibility criteria
- -Patients aged 18 years or older and under 80 years
- -Emergency or semi-emergency abdominal surgery of the following types: -urological -gastrointestinal -gynecological
- -Open or laparoscopic surgery
- -Estimated duration of surgery ≥ 60 minutes
- Informed consent for competent patients. Consent from the designated representative, or emergency procedure, followed by obtaining the patient’s consent to continue treatment after surgery
- -Use of a regional anesthesia technique via epidural analgesia
- -Pregnancy or breastfeeding. Women of childbearing age will undergo a pregnancy test prior to enrollment. -Porphyria
- Porphyria
- Surgery in Connection with a Transplant
- - Contraindications to lidocaine: § Known hypersensitivity to lidocaine, excipients, or amide-type local anesthetics. § Complete heart block § Hypovolemia - Contraindications to treatment with 0.9% NaCl: § Hyperchloremia § Hypernatremia § Severe cases of fluid overload and water-sodium retention, particularly in cases of decompensated heart failure, decompensated liver failure (edematous-ascitic cirrhosis), preeclampsia/ eclampsia.
- - Patients under legal guardianship, conservatorship, or judicial protection.
- -Uncorrected high-degree atrioventricular block, chronic treatment with Class I antiarrhythmic drugs
- -Shock defined by a systolic blood pressure ≤ 90 mmHg upon admission to the emergency operating room
- -Respiratory failure defined by a respiratory rate > 25 breaths/min and/or a pulse oximetry O₂ saturation < 90% upon admission to the emergency operating room
- -Neurological failure defined by a Glasgow Coma Scale score ≤ 13 upon admission to the emergency operating room
- Known dementia
- -Active drug users or those undergoing withdrawal, given the significant challenges in managing perioperative analgesia in these patient
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.