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Tests treatment safety and results for Ulcerative Colitis (UC)
Official title Efficacy and Safety of Vedolizumab Combined With Upadacitinib in Patients With Ulcerative Colitis
ClinicalTrials.gov ID: NCT06095596
What this study is testing
What is Upadacitinib?
Upadacitinib is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for ulcerative colitis (uc).
Also referred to as Upadacitinib treatment.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- It's of great importance to effectively induce and maintain disease remission in patients with moderate to severe ulcerative colitis (UC). Vedolizumab (VDZ) is known for its high safety profile and confirmed therapeutic efficacy in UC treatment.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Diagnosed UC for at least 3 months, including endoscopic evidence supporting UC and histopathological evidence supporting UC diagnosis
- Suffering from moderate to severe UC, defined as modified Mayo score ≥ 4 and endoscopic subscale (ESS) ≥ 2
- Indications for VDZ or UPA application
You likely can't join if
- Patients who are unable to take oral UPA and receive regular intravenous VDZ infusion therapy
- Evidence of toxic megacolon was found during screening
- Previously underwent extensive colectomy, subtotal resection, or total colectomy, ileostomy, or colostomy due to UC
- people who require surgery due to UC or plan to undergo elective surgery during the study period
- There is evidence indicating that the people suffer from severe, progressive, or uncontrolled kidney, liver, blood, endocrine, respiratory, mental...
- Evidence of active hepatitis B or C infection during screening
The study team makes the final eligibility decision.
Where it's taking place
- Guangzhou, Guangdong, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Guangzhou, Guangdong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.