Clinical trial for End-stage Renal Disease
Official title The Microcirculation, Dialysis Modality and Sequestered Salt
ClinicalTrials.gov ID: NCT06327750
What this study is testing
- What it's testing
- The aim of this clinical trial is to investigate the effect of 5 different dialysis treatments (combinations of dialysis mode and dialysis fluid sodium content) on the microcirculation (MC) and sequestered sodium content (SSC) in adult prevalent end-stage kidney disease (ESKD) patients treated with hemodialysis (HD) or hemodiafiltration (HDF). The main questions it aims to answer are: 1.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years
- Treatment with HD or HDF 3 x per week during at least 4 hours for at least 3 months
- Blood flow rate feasiblity of ≥350 ml/min
- Residual diuresis \<200 ml/day
- Plasma Na before dialysis 137-145 mmol/L at baseline
You likely can't join if
- Severe incompliance to dialysis procedure and accompanying prescriptions, especially frequency and duration of dialysis treatment
- Life expectancy \< 3 months due to non-renal disease
- Expected transplantation within 6 months
- Access recirculation \> 10%
- Participation in another clinical intervention trial
- Metal implants (e.g. implantable cardioverter defibrillators)
See the full eligibility criteria
- Age ≥18 years
- Treatment with HD or HDF 3 x per week during at least 4 hours for at least 3 months
- Blood flow rate feasiblity of ≥350 ml/min
- Residual diuresis \<200 ml/day
- Plasma Na before dialysis 137-145 mmol/L at baseline
- spKt/Vurea ≥ 1.2
- Ability to understand study procedures and willingness to provide informed consent
- Severe incompliance to dialysis procedure and accompanying prescriptions, especially frequency and duration of dialysis treatment
- Life expectancy \< 3 months due to non-renal disease
- Expected transplantation within 6 months
- Access recirculation \> 10%
- Participation in another clinical intervention trial
- Metal implants (e.g. implantable cardioverter defibrillators)
- Severe obesity (MRI Ø 60 cm ≈ abdominal circumference ≤ 188 cm)
- Claustrophobia
The study team makes the final eligibility decision.
Where it's taking place
- Amstelveen, North Holland, Netherlands
- Amsterdam, North Holland, Netherlands
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Amstelveen, North Holland, Netherlands; Amsterdam, North Holland, Netherlands. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.