Clinical trial for Obesity
Official title Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity
ClinicalTrials.gov ID: NCT06335771
What this study is testing
- What it's testing
- The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70. Healthy volunteers may be eligible.
You may be able to join if
- age: ≥18 but ≤70 years
- not pregnant or breastfeeding
- weight stable and sedentary before enrollment
- no use tobacco products, excessive amounts of alcohol, or dietary supplements, or medications known to or suspected to affect glucose and lipid...
- no evidence of significant organ system dysfunction or disease (e.g. chronic severe kidney disease, cancer)
You likely can't join if
- \- Individuals that do not meet all inclusion Criterion
See the full eligibility criteria
- age: ≥18 but ≤70 years
- not pregnant or breastfeeding
- weight stable and sedentary before enrollment
- no use tobacco products, excessive amounts of alcohol, or dietary supplements, or medications known to or suspected to affect glucose and lipid metabolism (aside from certain medications used to treat diabetes in the...
- no evidence of significant organ system dysfunction or disease (e.g. chronic severe kidney disease, cancer)
- participants must fulfil all of the following group-specific below: Lean group:
- Body mass index (BMI) ≥18.5 but \<25.0 kg/m2
- Intrahepatic triglyceride (IHTG) content \<5%
- fasting blood glucose concentration: \<100 mg/dl
- blood glucose concentration 2 h after a 75 g oral glucose challenge: \<140 mg/dl
- Hemoglobin A1C (HbA1c) \<5.7 % Metabolically normal obesity (MNO) group:
- BMI ≥30.0 but \<45.0 kg/m2
- IHTG content \<5%
- fasting blood glucose concentration: \<100 mg/dl
- blood glucose concentration 2 h after a 75 g oral glucose challenge: \<140 mg/dl
- HbA1c \<5.7 % Metabolically abnormal obesity (MAO)-insulin resistance and non-alcoholic fatty liver disease (NAFLD) group:
- BMI ≥30.0 but \<45.0 kg/m2
- IHTG content \>7.5%
- fasting blood glucose concentration: ≥100 but \<126 mg/dl
- blood glucose concentration 2 h after a 75 g oral glucose challenge: ≥140 but \<200 mg/dl
- HbA1c: ≥5.7 but \<6.4 % MAO-type 2 diabetes group:
- BMI ≥30.0 but \<45.0 kg/m2
- clinical diagnosis of type 2 diabetes or fasting blood glucose concentration \>126 mg/dl or blood glucose concentration 2 h after a 75 g oral glucose challenge\>200 mg/dl or HbA1c \>6.4 % without medication if not...
- \- Individuals that do not meet all inclusion Criterion
The study team makes the final eligibility decision.
Where it's taking place
- Columbia, Missouri, United States
Compensation & support
This study's listing mentions compensation or reimbursement.
No amount is published here - ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Columbia, Missouri, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.