BridgeMD
New treatment option for Opioid Use Disorder
Official title Semaglutide for Helping Opioid Recovery
ClinicalTrials.gov ID: NCT06639464
What this study is testing
What is Semaglutide?
Semaglutide is an investigational medicine, given as an once-weekly injectable medicine, being studied as a potential treatment for opioid use disorder.
Also referred to as Ozempic.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The is a pilot, 12-week, double-blind, placebo-controlled, randomized trial of individuals with opioid use disorder (OUD) newly initiating buprenorphine to receive either weekly injections of semaglutide (n=23) or matching placebo (n=23). The primary aim is to determine the effects of semaglutide on cue-reactivity among individuals with OUD.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- English speaking adults aged 18 and above
- DSM-5 diagnosis of opioid use disorder, severe
- Initiated sublingual buprenorphine (SL-BUP) treatment within 60 days of enrollment
- Attained stable dosing of SL-BUP of 16mg or greater for 30 days prior to enrollment
- Anticipating continuation of SL-BUP for the duration of the trial
See the full eligibility criteria
- English speaking adults aged 18 and above
- DSM-5 diagnosis of opioid use disorder, severe
- Initiated sublingual buprenorphine (SL-BUP) treatment within 60 days of enrollment
- Attained stable dosing of SL-BUP of 16mg or greater for 30 days prior to enrollment
- Anticipating continuation of SL-BUP for the duration of the trial
- Agreeable with bringing SL-BUP prescription to visits to allow study team to conduct a dose count
- Willing to grant study team permission to communicate about SL-BUP treatment with community prescriber via completion of 42 CFR release Individuals with any of the following will be excluded:
- DSM-5 diagnosis of any current substance use disorder excluding opioid, cannabis or tobacco
- Active psychosis, active suicidality or homicidality or any psychiatric condition that impair ability to provide informed consent
- Any current or lifetime diagnosis of eating disorders
- BMI\<25mg/kg2
- Current or lifetime diagnosis of Type 1 or Type 2 diabetes
- Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
- Use of any GLP-1 agonist medications in the prior 3 months
- Anticipating receipt of any GLP-1 agonist medications during the trial
- History of angina pectoris, coronary heart disease, congestive heart failure, inflammatory bowel disease, chronic obstructive pulmonary disease, bariatric surgery, idiopathic pancreatitis, diabetic gastroparesis
- Liver function test greater than 3 times upper normal limit
- Renal impairment as indicated by eGFR of \<60
- History of hypersensitivity or allergy to semaglutide
- Pregnant or breastfeeding
- Anticipated to participate in a concurrent drug trial
- Any other reason or clinical condition that the investigators judge may interfere with study participation and/or be unsafe for a participant
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.