Clinical trial for Depression
Official title Pharmacologic Augmentation of TMS for Depression With D-serine
ClinicalTrials.gov ID: NCT06876129
What this study is testing
What is D-serine?
D-serine is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for depression.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this study is to test whether combining D-serine with 30 treatments of a) iTBS and b) 18-Hz protocols will enhance clinical outcomes compared to rTMS with placebo (i.e., sugar pill). The investigators hypothesize that NMDA receptor activation via D-serine combined with repeated sessions of rTMS will produce greater clinical outcomes than iTBS with placebo and 18-Hz with placebo.
- Phase 1: an early, usually small safety study
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Clinical diagnosis of MDD
- English-speaking
- Adults aged 18-80
- Must be able to swallow capsules Relative contraindications/possible
You likely can't join if
- Containing any implanted metal or devices
- Current or previous seizure history
- Active substance use that may significantly alter the seizure threshold Any further safety clearances, and outpatient consultation opinions that are...
- Patients with pre-existing renal disease
- Known allergy to D-serine, or with
- Patients taking medications with known drug-drug interactions
See the full eligibility criteria
- Clinical diagnosis of MDD
- English-speaking
- Adults aged 18-80
- Must be able to swallow capsules Relative contraindications/possible
- Containing any implanted metal or devices
- Current or previous seizure history
- Active substance use that may significantly alter the seizure threshold Any further safety clearances, and outpatient consultation opinions that are necessitated based on the answers to the screening will be obtained...
- Patients with pre-existing renal disease
- Known allergy to D-serine, or with
- Patients taking medications with known drug-drug interactions
- Children
- Pregnant or breast-feeding women The investigators will not include children because prior safety and dosing studies excluded children. Although considered safe for TMS, the investigators will not include pregnant or...
The study team makes the final eligibility decision.
Where it's taking place
- Belmont, Massachusetts, United States
Compensation & support
This study's listing mentions compensation or reimbursement.
No amount is published here - ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Belmont, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.