Clinical trial for Osteoarthritis (OA) of the Knee
Official title Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis
ClinicalTrials.gov ID: NCT07178951
What this study is testing
- What it's testing
- This study involves the use of sound waves to block pain signals caused by osteoarthritis of the knee. The sound waves are tightly focused on a specific area of the nerve.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Moderate to severe, predominantly medial chronic knee pain
- Age adult \>18 years old
- WOMAC Score of 30 or higher
- NRS\>6 with ambulation
- Radiological confirmation of knee osteoarthritis (Kellgren-Lawrence Scale: 2-4)
You likely can't join if
- Individuals meeting any of the following criteria are not eligible for participation in this study:
- Individuals after any surgery associated with altered integrity of bone structure
- Individuals with severe pain in the second knee
- Individuals unable to understand and complete the research questionnaires in the official language
- Individuals presenting with any severe medical condition preventing the participant from safely and effectively being treated in the study or...
- Individuals with extensive scarring of the skin and tissue overlying the treatment area
See the full eligibility criteria
- Moderate to severe, predominantly medial chronic knee pain
- Age adult \>18 years old
- WOMAC Score of 30 or higher
- NRS\>6 with ambulation
- Radiological confirmation of knee osteoarthritis (Kellgren-Lawrence Scale: 2-4)
- Participants in whom the measured skin to bone depth is 2-6 cm using imaging ultrasound and ultrasound gel pad in the upper medial and lower medial joint capsule targets.
- Individuals meeting any of the following criteria are not eligible for participation in this study:
- Individuals after any surgery associated with altered integrity of bone structure
- Individuals with severe pain in the second knee
- Individuals unable to understand and complete the research questionnaires in the official language
- Individuals presenting with any severe medical condition preventing the participant from safely and effectively being treated in the study or reporting study outcomes, per PI decision
- Individuals with extensive scarring of the skin and tissue overlying the treatment area
- Individuals enrolled in or planned to be enrolled in another clinical trial during the duration of this research project
- Individuals with active inflammatory (e.g., rheumatoid) arthritis
- Individuals with concomitant mental health disorders, excluding compensated mood disorders
- Individuals with altered perception and processing of pain: Average NRS \> 9, PCS\>30, SSS-8 \> 11, CSI\>40 [46], [47], [48]
- Individuals with a first-degree family member already enrolled in this study
- Individuals who are scheduled for any treatment/surgical procedure within 3 months from the screening date, excluding trivial surgeries (e.g., cataract, skin tumors)
- Inability to attend follow-up visits and physiotherapy due to travel distance or other restrictions
- Symptomatic multifocal nociplastic chronic pain (e.g., fibromyalgia, generalized osteoarthritis) or any other chronic pain condition that could influence symptoms.
- Participants who have undergone radiofrequency ablation of the genicular nerves in the planned treatment limb within the preceding 6 months.
The study team makes the final eligibility decision.
Where it's taking place
- North York, Ontario, Canada
Compensation & support
A stipend or payment for your time may be offered.
No amount is published here - ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include North York, Ontario, Canada. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.