Clinical trial for PARKINSON DISEASE (Disorder)
Official title Myrosinase Bioactivated Gglucoraphanin for the Treatment of Neurodegenerative Diseases (GRA-MYR-ND)
ClinicalTrials.gov ID: NCT07360977
What this study is testing
What is bioactivated GRA for adult patients?
bioactivated GRA for adult patients is an investigational medicine, being studied as a potential treatment for parkinson disease (disorder).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Glucosinolates (GLs) are phytocompounds mainly found in the Cruciferae (Brassicacea) and Moringa oleifera plants. The hydrolysis of GLs by myrosinase led to the production of isothiocyanate (ITCs).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 1 to 75
You may be able to join if
- for PD:
- Male or female patients aged between 45-75 years old.
- Clinical diagnosis of PD according to UK Brain Bank Criteria.
- 3 months of clinical stability before study enrolment.
- Anti-parkinsonian medication is fixed for at least 3 months prior to study entry. for MS:
You likely can't join if
- Exclusion criteria for PD and MS:
- Absolute contraindications to Magnetic Resonance Imaging (MRI).
- Concomitant neurological disease or severe co-morbidities able to influence outcomes such as spinal injury, cancer, dementia, or other central...
- Total score of Mini-Mental State Examination (MMSE)\<24.
- Participating in other clinical trials.
- Pregnant/lactating.
See the full eligibility criteria
- for PD:
- Male or female patients aged between 45-75 years old.
- Clinical diagnosis of PD according to UK Brain Bank Criteria.
- 3 months of clinical stability before study enrolment.
- Anti-parkinsonian medication is fixed for at least 3 months prior to study entry. for MS:
- Male or female patients 18 years old or older.
- Diagnosis of RR-MS according to McDonald criteria.
- Expanded Disability Status Scale(EDSS) lower or equal to 5.5.
- Stable disease for at least 30 days prior to study entry.
- Stable disease-modifying therapy for at least 3 months prior to study entry. Common for MS and PD:
- No changes in drug treatment during 6 months-study treatment.
- Patients understand and comply with the study procedure and are able to complete tests and examinations required by the project.
- Written informed consent. for pediatric patients:
- Eligible patients are those clinically stable;
- Age range from 1 to 10, between 5 and 30 kg.
- Patients not involved in other clinical trials.
- Exclusion criteria for PD and MS:
- Absolute contraindications to Magnetic Resonance Imaging (MRI).
- Concomitant neurological disease or severe co-morbidities able to influence outcomes such as spinal injury, cancer, dementia, or other central nervous system diseases such as stroke, epilepsy or psychiatric disorders;
- Total score of Mini-Mental State Examination (MMSE)\<24.
- Participating in other clinical trials.
- Pregnant/lactating.
The study team makes the final eligibility decision.
Where it's taking place
- Messina, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 1 year to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Messina, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.