Trial studying safety and effects for Thrombosis
Official title Safety of Perioperative Anticoagulation Management in People With Active Cancer Undergoing Cancer-Related Surgery or Procedures (ACE-HIGH Study)
ClinicalTrials.gov ID: NCT07372716
What this study is testing
- What it's testing
- The study looks at how well current blood‑thinner management works for cancer patients undergoing surgery or procedures and measures how often bleeding or clotting problems occur.
- Who it's for
- Cancer patients who are scheduled for surgery or medical procedures and are on blood thinners.
- What's involved
- Participants will follow their usual blood‑thinner regimen, have blood tests to check drug levels, and be monitored for bleeding or clotting events during and after the procedure.
- Time commitment
- The study lasts from the day of the procedure through the recovery period, with follow‑up visits and tests as needed to track safety outcomes.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years
- Prescribed a Direct Oral Anticoagulant (DOAC), warfarin (International Normalized Ratio (INR) target 2.0-3.0) or Low Molecular Weight Heparin (LMWH)...
- Has active cancer, defined as: i. cancer diagnosed within 6 months ii. recurrent, regionally advanced, or metastatic cancer iii.
- Is undergoing a planned cancer-related inpatient or outpatient invasive procedure or cancer surgery (to diagnose, treat or palliate cancer
- Interruption of anticoagulation therapy for the planned procedure is required.
You likely can't join if
- Presence of any mechanical prosthetic heart valve
- Known pregnancy or breastfeeding
- Severe renal insufficiency (Creatinine Clearance (CrCl) \< 30 mL/min or \< 25 mL/min for Apixaban users)
- Condition that might impair adherence to the study protocol (e.g., cognitive impairment, geographic inaccessibility) as determined by the treating...
- Allergy to heparin or a history of (Heparin Induced Thrombocytopenia (HIT)
- More than one surgery/procedure planned during the study period
See the full eligibility criteria
- Age ≥ 18 years
- Prescribed a Direct Oral Anticoagulant (DOAC), warfarin (International Normalized Ratio (INR) target 2.0-3.0) or Low Molecular Weight Heparin (LMWH) (75-100% weight-based therapeutic dosing) for stroke prevention in...
- Has active cancer, defined as: i. cancer diagnosed within 6 months ii. recurrent, regionally advanced, or metastatic cancer iii. cancer for which treatment had been administered within 6 months before enrolment iv.
- Is undergoing a planned cancer-related inpatient or outpatient invasive procedure or cancer surgery (to diagnose, treat or palliate cancer; at investigator's discretion)
- Interruption of anticoagulation therapy for the planned procedure is required.
- Presence of any mechanical prosthetic heart valve
- Known pregnancy or breastfeeding
- Severe renal insufficiency (Creatinine Clearance (CrCl) \< 30 mL/min or \< 25 mL/min for Apixaban users)
- Condition that might impair adherence to the study protocol (e.g., cognitive impairment, geographic inaccessibility) as determined by the treating physician
- Allergy to heparin or a history of (Heparin Induced Thrombocytopenia (HIT)
- More than one surgery/procedure planned during the study period
- Previous study participation
- Inability to provide informed consent
The study team makes the final eligibility decision.
Where it is enrolling
- Ottawa, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Ottawa, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.