PET/CT imaging with FAPI to predict response to anti-inflammatory therapy in patients with fibrotic interstitial lung disease: “The FIBRO-PET Study”
EU CTIS ID: 2023-503686-26-02
What this study is testing
To evaluate whether baseline pulmonary FAPI uptake on PET/CT differs between subsequent responders and non-responders to a clinically indicated modification of anti-inflammatory therapy in patients with fibrotic ILD, and to estimate the magnitude and uncertainty of this difference.
- Phase I and Phase II (Integrated)- Other
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- ≥ 18 years of age
- Interstitial Lung Disease with fibrotic changes on HRCT or histopathological analysis
- A documented clinical indication to initiate, change, or intensify systemic anti-inflammatory/immunosuppressive therapy because of insufficiently controlled or progressive fibrotic ILD
- Reliable baseline pulmonary function test capturing a valid baseline Forced Vital Capacity (FVC) measurement within 4 weeks prior to the scheduled baseline FAPI-PET/CT scan
You likely can't join if
- Current or recent use of antifibrotic therapy: ongoing treatment with any antifibrotic drug, planned initiation or addition of antifibrotic therapy at baseline, or prior antifibrotic treatment discontinued less than 4 weeks before the scheduled baseline FAPI-PET/CT scan
- Active malignancy
- Inability to undergo a PET/CT at the Sint Antonius Hospital
- Incapacity to give informed consent personally
- Pregnancy
The study team makes the final eligibility decision.
Where it's taking place
- Netherlands
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Netherlands. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from EU CTIS. The study team decides eligibility, and your own doctor gives medical advice.