Post-traumatic Stress Disorder study: Device-Guided Breathing
Official title Sympathetic Overactivity in Post-traumatic Stress Disorder
ClinicalTrials.gov ID: NCT01627301
What this study is testing
- What it's testing
- This study is testing whether 8 weeks of daily DGB therapy or transcutaneous vagus nerve stimulation can reduce nervous system overactivity at rest and during stress.
- Who it's for
- You may be able to join if you have PTSD and prehypertension and are willing to try a daily therapy for 8 weeks.
- What's involved
- You will use a small device at home each day to receive either DGB or tVNS therapy. The team will check your nervous system activity at the start and after 8 weeks.
- Time commitment
- The study lasts 8 weeks, with a baseline check and a follow‑up check after the final week of therapy.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- prehypertensive and normotensive veterans with PTSD, and prehypertensive and normotensive veterans without PTSD (controls)
You likely can't join if
- heart or vascular disease
- illicit drug use within the last 6 months
- excessive alcohol use (\>2 drinks per day)
- pregnancy
- autonomic dysfunction
- medications known to affect SNS (clonidine)
See the full eligibility criteria
- prehypertensive and normotensive veterans with PTSD, and prehypertensive and normotensive veterans without PTSD (controls)
- heart or vascular disease
- illicit drug use within the last 6 months
- excessive alcohol use (\>2 drinks per day)
- pregnancy
- autonomic dysfunction
- medications known to affect SNS (clonidine)
- treatment with monoamine oxidase (MAO) inhibitors within the last 14 days
- any serious systemic disease
The study team makes the final eligibility decision.
Where it is enrolling
- Decatur, Georgia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Decatur, Georgia, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.