Post-bariatric Surgery study: Exendin- vs Exendin -
Official title Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
ClinicalTrials.gov ID: NCT01803451
What this study is testing
What is exendin-(9-39)?
This is an investigational medicine being studied to help researchers understand how gastric bypass surgery affects blood sugar control. It is designed to block the action of natural gut hormones that normally stimulate insulin release, allowing doctors to measure how much insulin your body produces on its own.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to learn why gastric bypass helps blood sugar by looking at gut hormones that boost insulin. It will compare hormone effects in people who feel low blood sugar after surgery, those who feel fine after surgery, and people who never had surgery.
- Who it's for
- Adults who have had gastric bypass surgery and may or may not experience low blood sugar after the operation.
- What's involved
- Participants will have blood tests and a special test that measures insulin and blood sugar while they drink or receive sugar. The study will also measure levels of a hormone called GLP‑1 that helps insulin release.
- Time commitment
- The study lasts a few weeks and involves several clinic visits for blood draws and the glucose‑insulin test.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- age 18-65
- healthy control without diabetes or active organ disease
- Individuals with bariatric surgery
- recurrent hypoglycemia post gastric bypass
You likely can't join if
- pregnancy
- significant anemia
- diabetes currently unless pre-op for bariatric surgery procedure
- GI obstruction
The study team makes the final eligibility decision.
Where it is enrolling
- San Antonio, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at San Antonio, Texas, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.