PPA study: AV-1451
Official title Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
ClinicalTrials.gov ID: NCT01818661
What this study is testing
What is AV-1451?
an investigational PET imaging agent being studied to assess tau burden in primary progressive aphasia (PPA). is designed to bind to tau protein aggregates in the brain and emit a signal that can be detected by PET scans.
Also referred to as flortaucipir.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is looking at how brain imaging changes relate to worsening speech and language in progressive apraxia of speech.
- Who it's for
- You may be able to join if you have progressive apraxia of speech or related primary progressive aphasia.
- What's involved
- You will have brain scans and speech and language tests at several visits. The scans will show brain structure and activity, and the tests will track your speech abilities.
- Time commitment
- The study lasts several years with regular check‑ins and imaging visits.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- We will study people that fulfill clinical for neurodegenerative AOS that have been seen and diagnosed at Mayo Clinic
You likely can't join if
- people with concurrent illnesses that could account for speech and language deficits, such as traumatic brain injury, strokes or developmental...
- Women that are pregnant or post-partum and breast-feeding will be excluded.
- people will also be excluded if MRI is contraindicated (metal in head, cardiac pace maker, e.t.c.), if there is severe claustrophobia, if there are...
- people will also be excluded if they do not have an informant, or do not consent to research.
The study team makes the final eligibility decision.
Where it is enrolling
- Rochester, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Rochester, Minnesota, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.