Clinical trial for Sleep Apnea
Official title Sleep Apnea in Elderly
ClinicalTrials.gov ID: NCT02703220
What this study is testing
What is Acetazolamide?
Acetazolamide is an investigational medicine being studied to see if it can help reduce breathing pauses in people with sleep apnea. It is designed to change the acidity of the blood, which may help the body breathe more regularly during sleep.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to find out if these three treatments can reduce unstable breathing and stop sleep apnea in older adults.
- Who it's for
- The study is looking for elderly veterans who have sleep apnea.
- What's involved
- Participants will receive one of the three treatments to see how it affects their breathing during sleep.
- Time commitment
- The source text does not specify the duration or visit schedule for this study.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 60 to 89. Healthy volunteers may be eligible.
You may be able to join if
- Adults with mild to moderate sleep apnea with Apnea-Hypopnea Index (AHI)\>/=5 to 20/hour with central, obstructive, mixed apneas and hypopneas
- For the finasteride protocol elderly men with above criteria will be enrolled
You likely can't join if
- Patients with severe sleep apnea (Apnea-Hypopnea Index (AHI)\>20/hour)
- Patients with history of prostate cancer
- Males with hypogonadism
- History of cardiac disease, including myocardial infarction
- Bypass surgery
- Atrial and ventricular tachy-bradycardias
See the full eligibility criteria
- Adults with mild to moderate sleep apnea with Apnea-Hypopnea Index (AHI)\>/=5 to 20/hour with central, obstructive, mixed apneas and hypopneas
- For the finasteride protocol elderly men with above criteria will be enrolled
- Patients with severe sleep apnea (Apnea-Hypopnea Index (AHI)\>20/hour)
- Patients with history of prostate cancer
- Males with hypogonadism
- History of cardiac disease, including myocardial infarction
- Bypass surgery
- Atrial and ventricular tachy-bradycardias
- Systolic congestive heart failure and Cheyne-Stokes respiration
- Current unstable angina
- Stroke
- Schizophrenia
- Untreated hypothyroidism
- Seizure disorder
- Preexisting renal failure and liver disorders
- Failure to give informed consent.
- Patients with significant pulmonary diseases by history and abnormal pulmonary function testing, including moderate obstructive/restrictive lung/chest wall disorders with resting oxygen saturation of \<96% or on...
- study drugs
- sympathomimetics/parasympathomimetics or their respective blockers
- narcotics
- antidepressants
- anti-psychotic agents
- other central nervous system (CNS) altering medications
- current alcohol, tobacco or recreational drug use
- Patients with Body mass index (BMI)\>34 kilograms per square meter (kg/m2) will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control
- Elderly with unstable gait or mobility issues that may preclude safe participation
- Individuals with allergy to finasteride or acetazolamide will be excluded from the specific protocol
- Pregnant women
The study team makes the final eligibility decision.
Where it is enrolling
- Detroit, Michigan, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 60 years to 89 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Detroit, Michigan, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.