Exacerbation Copd study: Non Invasive Ventilation vs High Flow Oxygen Cannula
Official title High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov ID: NCT03033251
What this study is testing
- What it's testing
- The study compares the physiological effects of high‑flow nasal cannula (HFNC) to non‑invasive ventilation (NIV) in patients with severe COPD exacerbations, aiming to show that HFNC is not worse than NIV.
- Who it's for
- Adults who have a severe flare‑up of chronic obstructive pulmonary disease and need breathing support.
- What's involved
- Participants will receive either HFNC or NIV, with regular monitoring of breathing and blood gases, and may have additional routine tests as needed.
- Time commitment
- The trial lasts for the duration of the hospital stay, with daily assessments and follow‑up visits as required by the study protocol.
This is a blinded study.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 and older
You may be able to join if
- COPD exacerbation and acute hypercapnic respiratory failure with acute respiratory failure defined by
- Respiratory acidosis (pH ≤7.35 and PaCO2 ≥45 mmHg);
- Respiratory rate≥20 breaths/min;
- Activation of accessory respiratory muscles;
- Undergone at NIV or HFNC since their admission
You likely can't join if
- Severe respiratory acidosis defined by pH\<7.25
- Decreased level of consciousness (Glasgow Coma Score Scale \< 11)
- Urgent intubation required
- Pneumothorax with pleural drainage and persistent air leak
- Hemodynamic instability requiring vasopressors
- Uncooperative
See the full eligibility criteria
- COPD exacerbation and acute hypercapnic respiratory failure with acute respiratory failure defined by
- Respiratory acidosis (pH ≤7.35 and PaCO2 ≥45 mmHg);
- Respiratory rate≥20 breaths/min;
- Activation of accessory respiratory muscles;
- Undergone at NIV or HFNC since their admission
- English speaking
- Adult patient with age \> 40 year old.
- Severe respiratory acidosis defined by pH\<7.25
- Decreased level of consciousness (Glasgow Coma Score Scale \< 11)
- Urgent intubation required
- Pneumothorax with pleural drainage and persistent air leak
- Hemodynamic instability requiring vasopressors
- Uncooperative
- Patients with skin or chest wall or abdominal trauma (potentially worsened by placement of a surface sensor)
- Clinical judgement of the attending physician
- Body mass index \> 40 kg/m2
The study team makes the final eligibility decision.
Where it is enrolling
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Toronto, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.