Clinical trial for Alzheimer Disease
Official title Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias
ClinicalTrials.gov ID: NCT03035851
What this study is testing
- What it's testing
- The study wants to see if regular aerobic exercise can improve thinking skills and brain health in people at higher risk for Alzheimer’s disease. It also looks at how any changes happen in the body and brain.
- Who it's for
- People aged 50 to 80 who have mild memory complaints, are not currently active, and do not have diagnosed dementia.
- What's involved
- Participants are randomly assigned to either an aerobic exercise program or a stretching‑toning program. They will attend supervised exercise sessions, undergo cognitive tests, blood draws, brain scans, and sleep questionnaires.
- Time commitment
- The program lasts 6 months, with follow‑up visits up to 12 months after the exercise ends to check lasting effects.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 to 80
You may be able to join if
- inactive men and women aged 50-80 years (inclusive) with subjective cognitive symptoms but no dementia who have one or more vascular risk factors...
- Inactivity will be assessed with a physical activity questionnaire and defined as engagement in \<3 sessions/week of 20 min or more of vigorous...
- Subjective cognitive symptoms will be self-reported using the MAC-Q Memory Complaint Questionnaire, recently validated as a measure of subjective...
- history of hypertension;
- diabetes mellitus;
You likely can't join if
- diagnosis of a developmental handicap;
- history of dementia (DSM-V criteria)\ \ ;
- terminal illness (life expectancy \< 1 year)
- not fluent in verbal and written English;
- history of stroke;
- currently participating in another trial;
See the full eligibility criteria
- inactive men and women aged 50-80 years (inclusive) with subjective cognitive symptoms but no dementia who have one or more vascular risk factors (see below) for ADRD;
- Inactivity will be assessed with a physical activity questionnaire and defined as engagement in \<3 sessions/week of 20 min or more of vigorous exercise;
- Subjective cognitive symptoms will be self-reported using the MAC-Q Memory Complaint Questionnaire, recently validated as a measure of subjective memory complaints in healthy elderly people, in patients with mild...
- history of hypertension;
- diabetes mellitus;
- obesity (body mass index (BMI) \<40 kg/m2)
- elevated cholesterol;
- currently smoking;
- past history of coronary artery disease without recent (\<5 years) symptoms. Participants must provide a completed PAR-Q+ form (www.csep.ca), the standard method of obtaining physician approval for participation in an...
- diagnosis of a developmental handicap;
- history of dementia (DSM-V criteria)\ \ ;
- terminal illness (life expectancy \< 1 year)
- not fluent in verbal and written English;
- history of stroke;
- currently participating in another trial;
- comorbid medical or neurological illnesses (e.g., multiple sclerosis) that would confound cognitive assessments or make trial completion unlikely (in the site investigator's opinion);
- contraindication for the intervention;
- contraindication for an MRI exam.
- \ \ Existing or suspected dementia will be identified by medical history, cognitive impairment on the Telephone Interview for Cognitive Status (TICS-modified
The study team makes the final eligibility decision.
Where it is enrolling
- Calgary, Alberta, Canada
Compensation & support
A stipend or payment for your time may be offered.
No amount is published here because ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team, so confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Calgary, Alberta, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.