Clinical trial for Obstructive Sleep Apnea of Adult
Official title Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
ClinicalTrials.gov ID: NCT03255408
What this study is testing
What is Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep?
This is an investigational study using a medicine to lower blood flow to the brain while sleeping in normal air to learn more about how the body controls breathing in people with obstructive sleep apnea.
Also referred to as Cerebral Blood Flow changes and Normoxia Sleep.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find out if lowering blood flow to the brain changes how the body reacts to low oxygen or high carbon dioxide levels.
- Who it's for
- The study is looking for adults who have obstructive sleep apnea.
- What's involved
- Participants will take part in a cross-over design where they receive either a real treatment or a placebo in a random order. They will undergo tests to measure breathing and blood flow.
- Time commitment
- The source text does not specify the total duration or the number of visits required.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 45. Healthy volunteers may be eligible.
You may be able to join if
- Healthy adults
- 18 - 45 years of age
- Living in Calgary for the past one year
- Have no medical condition or should not be taking any blood pressure medications.
- The participant should not be lactose intolerant
You likely can't join if
- Cerebrovascular, cardio-respiratory, renal and metabolic diseases
- Bleeding disorders and upper gastrointestinal diseases e.g. peptic ulcer disease
- Pregnancy, obese and sleep-disordered breathing
- Drug allergies to non-steroidal anti-inflammatories
- Currently smoking
The study team makes the final eligibility decision.
Where it is enrolling
- Calgary, Alberta, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 45 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Calgary, Alberta, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.