Anxiety study: Buspirone vs Triazolam
Official title Measurement of the Hippocampal Theta Rhythm From the Outer Ear Canal
ClinicalTrials.gov ID: NCT03954483
What this study is testing
What is Buspirone 10 mg Oral Tablet?
An investigational oral medication being studied for anxiety.
Also referred to as Buspirone.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to see if signals from the outer ear can reveal the brain’s theta rhythm, which is linked to anxiety, using a new technology.
- Who it's for
- Healthy adults who can safely take two different medications.
- What's involved
- Participants will receive two different drugs in a double‑blind setup while an ear‑mounted sensor records vestibular signals that may reflect theta rhythm.
- You might receive a placebo (an inactive treatment) instead of the study drug. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 40. Healthy volunteers may be eligible.
You may be able to join if
- Males and females who are between 18 and 40 years of age.
You likely can't join if
- Psychological treatment in the past year or taking any psychiatric drug.
- Drugs that interact with the study drugs or that have anxiolytic/anxiogenic properties.
- Antibiotics or natural health products that inhibit/induce CYP3A4 or CYP2D6.
- History of substance use disorder or family history of substance use disorder.
- Pregnancy (or breastfeeding), left handedness, or colour blindness.
- Individuals who have a current diagnosis, or history of, a neurological illness.
See the full eligibility criteria
- Males and females who are between 18 and 40 years of age.
- Psychological treatment in the past year or taking any psychiatric drug.
- Drugs that interact with the study drugs or that have anxiolytic/anxiogenic properties.
- Antibiotics or natural health products that inhibit/induce CYP3A4 or CYP2D6.
- History of substance use disorder or family history of substance use disorder.
- Pregnancy (or breastfeeding), left handedness, or colour blindness.
- Individuals who have a current diagnosis, or history of, a neurological illness.
- A history of stroke, head injury, loss of consciousness, epilepsy.
- Kidney or liver disease/impairment.
- COPD or sleep apnea.
- Skin lesions involving the ear canal, self-reported or as assessed in examination at the lab.
- Any unknown balance disorders, as assessed by investigator via balance test.
- Major hearing loss, self-reported or as assessed by investigator via audiogram.
- Allergic skin reactions to chemical agents including detergents.
- Heart disease, lung disease or diabetes.
- Influenza, Covid-19, or flu-like symptoms.
- Recovering from an accident, injury, or operation.
The study team makes the final eligibility decision.
Where it is enrolling
- Winnipeg, Manitoba, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 40 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Winnipeg, Manitoba, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.