Huntington Disease study: Brain MRI vs Lumbar Punction
Official title Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease
ClinicalTrials.gov ID: NCT04012411
What this study is testing
What is Blood sample?
Blood sample is an investigational medicine, being studied as a potential treatment for huntington disease.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find biological markers in the blood and spinal fluid that show how a key brain chemical pathway is affected in Huntington's disease.
- Who it's for
- The study is looking for people who have been diagnosed with Huntington's disease.
- What's involved
- Participants will provide blood and spinal fluid samples so researchers can analyze them for specific markers.
- Time commitment
- The source text does not specify the duration of the study or the number of visits required.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- General
- age ≥ 18 years-old
- national health insurance cover
- Patients
- genetically confirmed Huntington's disease diagnosis (≥ 35 CAG repeat in HTT gene exon 1)
You likely can't join if
- protected by law
- Huntington's disease stage too Evolved that may interfere with cognitive evaluations or MRI
- contraindications to brain MRI
- only for patients "with LP": contraindications to LP
- incapacity to give informed consent
- neurodegenerative of inflammatory central nervous system pathology
See the full eligibility criteria
- General
- age ≥ 18 years-old
- national health insurance cover
- Patients
- genetically confirmed Huntington's disease diagnosis (≥ 35 CAG repeat in HTT gene exon 1)
- written informed consent
- only for patients "with lumbar puncture (LP)": patient agreement for LP
- Control
- anterior LP for medical reason with consent for biobank "Neuro" with following samples present in this biobank : 2 mL blood + 0.5 mL plasma + 0.5 mL cerebrospinal fluid
- information and non-opposition for the finality of this biobank
- paired by age with a patient (+/- 5 years difference)
- protected by law
- Huntington's disease stage too Evolved that may interfere with cognitive evaluations or MRI
- contraindications to brain MRI
- only for patients "with LP": contraindications to LP
- incapacity to give informed consent
- neurodegenerative of inflammatory central nervous system pathology
The study team makes the final eligibility decision.
Where it is enrolling
- Montpellier, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Montpellier, France. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.