Clinical trial for Diabetes Mellitus, Type 2
Official title Phenotyping Genetic Risk for Type 2 Diabetes
ClinicalTrials.gov ID: NCT04024631
What this study is testing
- What it's testing
- The study aims to see whether a high genetic risk score is linked to impaired glucose tolerance and insulin resistance in people who do not yet have diabetes.
- Who it's for
- Adults who do not have diabetes but have been tested for a high or low genetic risk score for type 2 diabetes.
- What's involved
- Participants will have their genetics tested and will undergo glucose tolerance and insulin resistance tests to compare results between high‑risk and low‑risk groups.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 10 to 70. Healthy volunteers may be eligible.
You may be able to join if
- Age 10-70 years
- Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
- Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
You likely can't join if
- prior diagnosis of type 1, type 2, or secondary diabetes
- use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
- acute illness that may impact insulin and glucose dynamics
- pregnancy
- hypothalamic obesity or related genetic disorder of metabolism
- recent systemic chemotherapy use
See the full eligibility criteria
- Age 10-70 years
- Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
- Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
- prior diagnosis of type 1, type 2, or secondary diabetes
- use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
- acute illness that may impact insulin and glucose dynamics
- pregnancy
- hypothalamic obesity or related genetic disorder of metabolism
- recent systemic chemotherapy use
- gastrointestinal impairment or surgery that may impact absorption
- anemia
- major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
- inability to comply with study protocol
The study team makes the final eligibility decision.
Where it is enrolling
- Philadelphia, Pennsylvania, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 10 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Philadelphia, Pennsylvania, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.