Schizophrenia study: [11C]UCB-J radiotracer vs PET-MR
Official title Imaging Synapses With [11C] UCB-J in the Human Brain
ClinicalTrials.gov ID: NCT04038840
What this study is testing
What is [11C]UCB-J radiotracer?
This is an investigational radioactive imaging agent being studied to help understand the brain changes in schizophrenia. It is designed to bind to specific proteins in the brain so that a PET scan can measure the density of synapses.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is looking at how many nerve connections are in the brain. It tests if people with schizophrenia have fewer of these connections.
- Who it's for
- You may be able to join if you have schizophrenia.
- What's involved
- You would get a special brain scan. This scan uses a safe, short-lived radioactive tracer to show nerve details.
- Time commitment
- The study involves one main visit for the brain scan.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- 18 - 65 years in age
- On a stable medication regimen for at least two weeks prior to testing
- A clinical diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
- Able to complete a PET-MR scan without the use of sedation
You likely can't join if
- Active substance use within three months of testing
- IQ \< 70
- Major medical neurological illness or significant head trauma
- Pregnancy or breastfeeding
- Contraindication to MR scanning, including magnetic-resonance incompatible metal or hardware including pacemakers, cochlear implants, and bullets...
- Weight \> 350 lbs or a large body habitus that MR scanner cannot accommodate
See the full eligibility criteria
- 18 - 65 years in age
- On a stable medication regimen for at least two weeks prior to testing
- A clinical diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
- Able to complete a PET-MR scan without the use of sedation
- Active substance use within three months of testing
- IQ \< 70
- Major medical neurological illness or significant head trauma
- Pregnancy or breastfeeding
- Contraindication to MR scanning, including magnetic-resonance incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ
- Weight \> 350 lbs or a large body habitus that MR scanner cannot accommodate
- History of or current claustrophobia
- Inability to comply with basic study requirements such as following directions and punctuality
- Presence of a first degree relative with a psychotic disorder
- Lifetime diagnosis of major psychiatric illness
- Unstable psychiatric symptoms at the time of testing, e.g. acute suicidality, prominent psychosis, or behavioral dyscontrol
The study team makes the final eligibility decision.
Where it is enrolling
- Palo Alto, California, United States
- Stanford, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Palo Alto, California, United States; Stanford, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.