Clinical trial for Obsessive-Compulsive Disorder
Official title Pragmatic Trial of Obsessive-compulsive Disorder
ClinicalTrials.gov ID: NCT04539951
What this study is testing
What is Sertraline 200 milligram(mg)?
Sertraline 200 milligram(mg) is an investigational medicine, being studied as a potential treatment for obsessive-compulsive disorder.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to see which switching or augmenting strategies work best for OCD when the initial treatment fails.
- Who it's for
- Adults with obsessive‑compulsive disorder whose first medication or therapy did not relieve their symptoms.
- What's involved
- Participants will try various medication adjustments or add‑on treatments, attend scheduled visits, and may have routine tests to monitor progress.
- Phase 2: a mid-size study of how well it works
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- They
- meet DSM-5 diagnostic criteria for OCD as the primary diagnosis ;
- are in the age range from 18 to 65 years;
- have a score of at least 20 on Yale-Brown Obsessive-Compulsive Scale (Y-BOCS);
- have never received medication for OCD, and have not received any form of psychotherapy for OCD in the past 1 month;
You likely can't join if
- They
- have met the DSM-5 diagnostic criteria for Schizophrenia Spectrum and Other Psychotic Disorders, or the Bipolar and Related Disorders;
- have a moderate or higher risk of suicide (⩾9 on the Suicide Module in the Mini-International Neuropsychiatric Interview (MINI));
- have substance use that is sufficiently severe to possibly impact negatively on treatment adherence in the past 1 year;
- have severe depression with Beck Depression Inventory (BDI) score of ≥29;
- have comorbid psychiatric or medical disorders that may impact negatively on adherence to or on the how well it works of medication (eg borderline...
See the full eligibility criteria
- They
- meet DSM-5 diagnostic criteria for OCD as the primary diagnosis ;
- are in the age range from 18 to 65 years;
- have a score of at least 20 on Yale-Brown Obsessive-Compulsive Scale (Y-BOCS);
- have never received medication for OCD, and have not received any form of psychotherapy for OCD in the past 1 month;
- have provided written informed consent.
- They
- have met the DSM-5 diagnostic criteria for Schizophrenia Spectrum and Other Psychotic Disorders, or the Bipolar and Related Disorders;
- have a moderate or higher risk of suicide (⩾9 on the Suicide Module in the Mini-International Neuropsychiatric Interview (MINI));
- have substance use that is sufficiently severe to possibly impact negatively on treatment adherence in the past 1 year;
- have severe depression with Beck Depression Inventory (BDI) score of ≥29;
- have comorbid psychiatric or medical disorders that may impact negatively on adherence to or on the how well it works of medication (eg borderline personality disorder, CNS disorders)；
- are pregnant or lactating females.
The study team makes the final eligibility decision.
Where it is enrolling
- Shanghai, Shanghai Municipality, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Shanghai, Shanghai Municipality, China. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.