Post Traumatic Stress Disorder study: Fear Conditioning
Official title Fear and Avoidance in PTSD Patients
ClinicalTrials.gov ID: NCT04770584
What this study is testing
- What it's testing
- The study wants to see how the brain reacts and how people feel when they learn to avoid certain stimuli, and how fear‑extinction training and monetary rewards change that avoidance.
- Who it's for
- Adults who have been diagnosed with post‑traumatic stress disorder (PTSD).
- What's involved
- Participants will take part in experimental tasks that involve avoiding specific stimuli while researchers record brain activity and ask about feelings and expectations.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70. Healthy volunteers may be eligible.
You may be able to join if
- 18 - 70 years of age
- Female or Male
- PTSD people a. Diagnosis of current PTSD
- Trauma-exposed healthy controls (TEHC)
- SCID diagnosis consistent with no current psychiatric disorders, and no current PTSD
You likely can't join if
- History of neurologic disease (e.g. tic disorder)
- Current significant suicidal ideation, plan or intent or suicidal behavior in past 6 months based on CSSRS or Self-injurious behavior that involves...
- History of seizure or significant head trauma
- History of the serious/significant psychiatric diagnosis ("Axis I" disorders)
- Use of neuroleptics within one year prior to study
- Current substance use (assessed by urine toxicology; positive urine toxicology screen for any substance, with the exception of THC).
See the full eligibility criteria
- 18 - 70 years of age
- Female or Male
- PTSD people a. Diagnosis of current PTSD
- Trauma-exposed healthy controls (TEHC)
- SCID diagnosis consistent with no current psychiatric disorders, and no current PTSD
- History of trauma exposure
- Healthy controls (HC)
- SCID diagnosis consistent with no current psychiatric disorders ("Axis I" disorders).
- No history of trauma exposure
- Willing and able to provide informed consent.
- History of neurologic disease (e.g. tic disorder)
- Current significant suicidal ideation, plan or intent or suicidal behavior in past 6 months based on CSSRS or Self-injurious behavior that involves suicidal intent, requires medical attention, or occurs daily
- History of seizure or significant head trauma
- History of the serious/significant psychiatric diagnosis ("Axis I" disorders)
- Use of neuroleptics within one year prior to study
- Current substance use (assessed by urine toxicology; positive urine toxicology screen for any substance, with the exception of THC).
- Pregnancy (to be ruled out by urine ß-HCG)
- Metallic implants or devices contraindicating magnetic resonance imaging
- Current psychiatric diagnosis ("Axis I" diagnoses)
The study team makes the final eligibility decision.
Where it is enrolling
- Houston, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Houston, Texas, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.