Clinical trial for Type 2 Diabetes
Official title Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes
ClinicalTrials.gov ID: NCT04791371
What this study is testing
- What it's testing
- The study wants to learn whether reduced insulin‑driven blood flow to muscles contributes to heart and muscle problems in type 2 diabetes, and if regular exercise can reverse those changes.
- Who it's for
- Adults who have type 2 diabetes and are overweight or obese.
- What's involved
- Participants will follow a supervised exercise training program and undergo tests that measure heart function, muscle performance, and blood flow to the heart and skeletal muscle.
- Time commitment
- The study runs for several weeks to months, with regular exercise sessions and periodic clinic visits for testing.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 55. Healthy volunteers may be eligible.
You may be able to join if
- Sedentary (defined as less than 1 hour per week of physical activity)
- BMI: 25-40
- Men and women with and without type 2 diabetes
You likely can't join if
- Documented cardiovascular disease
- Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110
- Obstructive pulmonary disease or asthma
- Peripheral neuropathy
- Physical impairment that would limit exercise ability
- people taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
See the full eligibility criteria
- Sedentary (defined as less than 1 hour per week of physical activity)
- BMI: 25-40
- Men and women with and without type 2 diabetes
- Documented cardiovascular disease
- Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110
- Obstructive pulmonary disease or asthma
- Peripheral neuropathy
- Physical impairment that would limit exercise ability
- people taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
- Current or past smoking within the last 1 years
- Current tobacco use
- Anemia
- Control HbA1c \> 5.7, T2DM HbA1c \> 9
- Pregnant, nursing or hormonal therapy (other than contraceptives)
- Peri or post-menopausal women
- Type 1 diabetes
- Hepatic or renal disease.
The study team makes the final eligibility decision.
Where it is enrolling
- Aurora, Colorado, United States
- Charlottesville, Virginia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 55 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Aurora, Colorado, United States; Charlottesville, Virginia, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.