Obsessive-Compulsive Disorder study: Fluoxetine vs Dextromethorphan
Official title Study of Dextromethorphan in OCD and Related Disorders
ClinicalTrials.gov ID: NCT04899687
What this study is testing
What is Fluoxetine?
This is an investigational prescription medicine being studied to see if it helps with symptoms of Obsessive-Compulsive Disorder when taken with another drug. It is designed to affect chemicals in the brain called neurotransmitters to help manage mood and anxiety.
Also referred to as Prozac.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether adding dextromethorphan to fluoxetine can relieve symptoms in OCD and related disorders.
- Who it's for
- You may be able to join if you have OCD, illness anxiety, body dysmorphic, or somatic symptom disorder and are not already on this medication combo.
- What's involved
- You will take dextromethorphan and fluoxetine as prescribed, and attend visits for check‑ins and safety monitoring.
- Time commitment
- The study lasts several weeks, with regular clinic visits to track your progress and any side effects.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65
You may be able to join if
- Diagnosis of obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD), illness anxiety disorder (IAD) or somatic symptom disorder (SSD)
- Living within California
- Capacity to provide informed consent
You likely can't join if
- Current bipolar disorder or psychotic disorder
- Active moderate or severe substance use disorder, lifetime severe substance use disorder
- Pregnant or nursing women
- Use of prescribed psychotropic medications other than fluoxetine for 2 weeks prior to study start
- Having commenced OCD-targeted exposure and response-prevention (ExRP) psychotherapy within 2 months of study start
The study team makes the final eligibility decision.
Where it is enrolling
- Stanford, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Stanford, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.