Prostate Cancer study: Lupron Depot
Official title Impact of Hormonal Therapy on Prostate Cancer Recurrence After Radical Prostatectomy
ClinicalTrials.gov ID: NCT05169112
What this study is testing
What is Lupron Depot?
Lupron Depot is an investigational injectable hormone therapy being studied as a potential adjuvant treatment to prevent prostate cancer recurrence after surgery. It is designed to lower testosterone levels by continuously stimulating and then down‑regulating the pituitary gland's release of luteinizing hormone.
Also referred to as leuprolide acetate.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether one year of hormone therapy after surgery stops cancer from returning. It also checks if this treatment is safe for men at high risk.
- Who it's for
- You may be able to join if you have just had prostate cancer surgery and are at high risk of the cancer coming back.
- What's involved
- You would get hormone therapy right after your surgery. You would also have regular check-ups to see how your body reacts.
- Time commitment
- The study lasts for one year of treatment plus later check-ins.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older, men only
You may be able to join if
- undetectable PSA (\<0.02 ng/ml) within 16 weeks post-operative;
- ≥25% predicted risk of PSA recurrence within 5 years of surgery (based on the Kattan nomogram)
You likely can't join if
- Unwilling to receive ADT;
- previously received ADT;
- lymph node metastases
- allergy to any form of ADT
The study team makes the final eligibility decision.
Where it is enrolling
- Halifax, Nova Scotia, Canada
- Ottawa, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling male, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Halifax, Nova Scotia, Canada; Ottawa, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.