Pulmonary Disease, Chronic Obstructive study: Aspirin
Official title Trial to Determine Effective Aspirin Dose in COPD
ClinicalTrials.gov ID: NCT05265299
What this study is testing
What is Aspirin 81mg?
This is an investigational daily pill being studied to see if it helps with breathing symptoms in people with chronic obstructive pulmonary disease (COPD). It is designed to stop small blood cells called platelets from clumping together, which may help reduce inflammation in the body.
Also referred to as Acetylsalicylic acid.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to find out if higher doses of aspirin can reduce inflammation and improve breathing in COPD patients, and whether blood or urine tests can predict who benefits.
- Who it's for
- Adults who have chronic obstructive pulmonary disease (COPD).
- What's involved
- Participants will take aspirin at assigned doses, attend clinic visits for blood and urine tests, and report breathing symptoms and flare‑ups.
- Time commitment
- The study lasts several months, with regular clinic visits for medication monitoring and testing.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 80
You may be able to join if
- Age ≥40 years
- Former smoker
- At least 10 pack-year smoking history
- Post-bronchodilator ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) \< 0.7
You likely can't join if
- History of myocardial infarction, percutaneous coronary intervention, or stroke
- Currently taking antiplatelet therapy (other than aspirin 81mg) or anticoagulant medication
- Contraindication to aspirin (including low platelet count, hematocrit \<25%, known aspirin-exacerbated respiratory disease, bleeding disorder...
- Oral corticosteroids within the past 6 weeks
- Currently taking immunosuppressant medication
- Active malignancy (other than non-melanoma skin cancer)
See the full eligibility criteria
- Age ≥40 years
- Former smoker
- At least 10 pack-year smoking history
- Post-bronchodilator ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) \< 0.7
- History of myocardial infarction, percutaneous coronary intervention, or stroke
- Currently taking antiplatelet therapy (other than aspirin 81mg) or anticoagulant medication
- Contraindication to aspirin (including low platelet count, hematocrit \<25%, known aspirin-exacerbated respiratory disease, bleeding disorder, history of bleeding or gastrointestinal (GI) ulcer, coagulopathy, or major...
- Oral corticosteroids within the past 6 weeks
- Currently taking immunosuppressant medication
- Active malignancy (other than non-melanoma skin cancer)
- Uncontrolled hypertension
- Pregnant or planning pregnancy in the next year
- Plans to move residence away from the immediate area within the next 3 months
The study team makes the final eligibility decision.
Where it is enrolling
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Baltimore, Maryland, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.