Glioblastoma study: Sonobiopsy vs Definity®
Official title Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma
ClinicalTrials.gov ID: NCT05281731
What this study is testing
What is Cancer Personalized Profiling?
Cancer Personalized Profiling is an investigational medicine, being studied as a potential treatment for glioblastoma.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This clinical study to evaluate sonobiopsy is significant because sonobiopsy will fundamentally enhance the clinician's insight into the molecular features of an intracranial lesion to tailor treatment approaches and optimize outcomes. In addition to the standard diagnostics of anatomic imaging and surgical histology, sonobiopsy has the potential to become the third pillar for brain tumor management by radically advancing the ability to easily and regularly acquire tumor genetic and molecular signatures.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Must be newly diagnosed with a lesion in the brain with imaging characteristics consistent with glioblastoma multiforme.
- Lesion must be \> 3 cm in maximal dimension on MRI.
- Lesion must be in the supratentorial space within 5 cm of the cortical surface.
- Lesion must be gadolinium enhancing.
- Low grade tumors and metastatic tumors
You likely can't join if
- Contraindication to MRI.
- Previous cranial surgery.
- Previous history of cancer and/or cancer treatments.
- Coagulopathy within 14 days of enrollment defined as PT/PTT outside of normal parameters and platelets \< 100,000/mcL.
- Physical skull defect of any kind.
- Ferrous material in the scalp or skull.
See the full eligibility criteria
- Must be newly diagnosed with a lesion in the brain with imaging characteristics consistent with glioblastoma multiforme. Scan must have occurred no more than 28 days prior to enrollment.
- Lesion must be \> 3 cm in maximal dimension on MRI.
- Lesion must be in the supratentorial space within 5 cm of the cortical surface.
- Lesion must be gadolinium enhancing.
- Low grade tumors and metastatic tumors
- Recurrent brain tumors and/or radiation necrosis
- Must be planning to undergo surgical resection of the tumor.
- Must be at least 18 years old.
- Patients with recurrent GBM who are planning to undergo surgical resection or laser ablation of the recurrent tumor. Recurrence must be confirmed on MRI performed no more than 28 days prior to enrollment.
- Contraindication to MRI.
- Previous cranial surgery.
- Previous history of cancer and/or cancer treatments.
- Coagulopathy within 14 days of enrollment defined as PT/PTT outside of normal parameters and platelets \< 100,000/mcL.
- Physical skull defect of any kind.
- Ferrous material in the scalp or skull.
- Scalp or skin disease that limits contact with the ultrasound probe.
- Enrolled in another clinical trial where intervention is administered prior to surgery.
- Known hypersensitivity to polyethylene glycol.
- Known unstable cardiopulmonary condition (e.g. acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, serious ventricular arrhythmias).
The study team makes the final eligibility decision.
Where it is enrolling
- St Louis, Missouri, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at St Louis, Missouri, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.