Hypothyroidism; Irradiation study: Levothyroxine
Official title TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients
ClinicalTrials.gov ID: NCT05316922
What this study is testing
What is Levothyroxine?
An investigational oral medication being studied for preventing hypothyroidism after radiation therapy. is designed to replace or supplement thyroid hormone in the body.
Also referred to as Thyroid drugs.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to see if suppressing TSH while children receive radiation to the thyroid can lower the chance of developing thyroid problems afterward.
- Who it's for
- Children who are undergoing radiation treatment that includes the thyroid gland.
- What's involved
- Participants will receive a medication that lowers TSH levels during their radiation sessions, and will have regular blood tests and clinic visits to monitor thyroid function.
- Time commitment
- The study lasts for the duration of the radiation treatment, with follow‑up visits and blood tests scheduled during and after therapy.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Adults
You may be able to join if
- Any patient with medulloblastoma, Hodgkin/non-Hodgkin Lymphoma before radiotherapy (RT) planning including thyroid parenchyma without previous...
- Written informed consent prior to any study-specific analysis and/or data collection.
You likely can't join if
- Any patient with medulloblastoma, Hodgkin/non-Hodgkin Lymphoma after radiotherapy including thyroid parenchyma;
- Not signed consent.
The study team makes the final eligibility decision.
Where it is enrolling
- Milan, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, not specified. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Milan, Italy. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.