Osteoarthritis Hand study: Surgical Denervation
Official title Efficacy of Surgical Joint Denervation in Painful Digital Osteoarthritis
ClinicalTrials.gov ID: NCT05378841
What this study is testing
- What it's testing
- The study aims to find out if cutting nerves around the finger joint can lessen pain and improve function in hand osteoarthritis.
- Who it's for
- Adults who have painful osteoarthritis affecting the joints of their fingers.
- What's involved
- Participants will have a surgery that removes nerve supply to the affected joint, followed by clinic visits and tests to measure pain and hand use.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years
- Patients with symptomatic digital osteoarthritis according to the criteria of the American College of Rheumatology
- 1 painful PIP joint (Analog digital scale ≥ 4/10) for more than 3 months
- having failed the usual medical treatment for a minimum of 3 months (level 1 analgesics, NSAIDs, infiltrations)
- Signature of informed consent
You likely can't join if
- digital osteoarthritis secondary to other known causes (eg gout, reactive arthritis, RA, psoriatic arthritis, spondyloarthropathies, septic arthritis)
- anesthetic contraindications to surgery or to performing an MRI
- Existence of a pain syndrome in the upper limbs, which would interfere with the assessment of AD.
- Fibromyalgia
- Use of oral, intramuscular or intra-articular or intravenous corticosteroids, immunosuppressants (methotrexate, sulfasalazine, leflunomide...
- Introduction of a new treatment for osteoarthritis of the hand in the previous month, including physiotherapy and fitting of a new finger orthosis.
See the full eligibility criteria
- Age ≥ 18 years
- Patients with symptomatic digital osteoarthritis according to the criteria of the American College of Rheumatology
- 1 painful PIP joint (Analog digital scale ≥ 4/10) for more than 3 months
- having failed the usual medical treatment for a minimum of 3 months (level 1 analgesics, NSAIDs, infiltrations)
- Signature of informed consent
- patient affiliated to a social security scheme
- knowing how to read French (for the questionnaires)
- digital osteoarthritis secondary to other known causes (eg gout, reactive arthritis, RA, psoriatic arthritis, spondyloarthropathies, septic arthritis)
- anesthetic contraindications to surgery or to performing an MRI
- Existence of a pain syndrome in the upper limbs, which would interfere with the assessment of AD.
- Fibromyalgia
- Use of oral, intramuscular or intra-articular or intravenous corticosteroids, immunosuppressants (methotrexate, sulfasalazine, leflunomide, biomedicines), hyaluronic acid infiltration in the finger joints in the...
- Introduction of a new treatment for osteoarthritis of the hand in the previous month, including physiotherapy and fitting of a new finger orthosis.
- History of denervation of the proximal interphalangeal joint (PIP)
- Patient under legal protection (guardianship or curatorship) and patient deprived of liberty
- Patient under AME
- Participation in another treatment research involving the human person or period of exclusion at the end of a previous research involving the human person.
The study team makes the final eligibility decision.
Where it is enrolling
- Paris, France
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Paris, France. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.