Non-small Cell Lung Cancer study: RMC-6236
Official title Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
ClinicalTrials.gov ID: NCT05379985
What this study is testing
What is RMC-6236?
This is an investigational oral tablet being studied as a potential treatment for non-small cell lung cancer. It is designed to block the active form of RAS proteins, which help cancer cells grow.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing how safe the drug is and what side effects it causes. It also looks at how well it works.
- Who it's for
- You may be able to join if you have advanced solid tumors with specific RAS mutations.
- What's involved
- You would take the drug RMC-6236. You would also have regular check-ups and tests.
- Time commitment
- The study lasts for a set time with regular visits to the clinic.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Histologically confirmed advanced solid tumor with specific KRAS G12 mutations (dose escalation) or RAS mutations (dose optimization/expansion)...
- Treatment naive or have received prior standard therapy appropriate for tumor type and stage
- Have Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Adequate organ function
You likely can't join if
- Primary central nervous system (CNS) tumors
- Active, untreated brain metastases
- Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication
- History of any other unstable or clinically significant concurrent medical condition that would, in the opinion of the investigator, jeopardize the...
The study team makes the final eligibility decision.
Where it is enrolling
- Orange, California, United States
- Santa Monica, California, United States
- Tampa, Florida, United States
- Atlanta, Georgia, United States
- Baton Rouge, Louisiana, United States
- Baltimore, Maryland, United States
- Boston, Massachusetts, United States
- New York, New York, United States
- Cincinnati, Ohio, United States
- Maumee, Ohio, United States
- Chattanooga, Tennessee, United States
- Nashville, Tennessee, United States
- Austin, Texas, United States
- Dallas, Texas, United States
- Houston, Texas, United States
- San Antonio, Texas, United States
- Salt Lake City, Utah, United States
- Fairfax, Virginia, United States
- Seattle, Washington, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Orange, California, United States; Santa Monica, California, United States; Tampa, Florida, United States; Atlanta, Georgia, United States; Baton Rouge, Louisiana, United States; Baltimore, Maryland, United States and 13 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.