Major Depressive Disorder study: Genetic testing
Official title Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
ClinicalTrials.gov ID: NCT05437588
What this study is testing
What is Genetic testing?
This is an investigational genetic test being studied to help identify markers for depression and suicide risk.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find biomarkers that link depression and suicidality and to see how standard depression treatment changes these markers and symptoms.
- Who it's for
- Adolescents who have major depressive disorder and suicidal thoughts or attempts.
- What's involved
- Participants will receive usual depression treatment and give blood samples to analyze microRNAs. They may also have routine visits and assessments.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 10 to 24. Healthy volunteers may be eligible.
You may be able to join if
- Physically healthy
- A definite diagnosis of DSM-5
- a Children's Depression Rating Scale-Revised (CDRS-R) score \>=30. Suicidal ideation participants: Columbia Suicide Severity Rating Scale (C-SSRS)...
You likely can't join if
- Pregnancy or lactation
- post-partum state (being within 2 months of delivery or miscarriage);
- homicide risk as determined by clinical interview
- any of the following DSM-V diagnoses or categories: a) a lifetime history of psychotic disorder
- recent myocardial infarction or unstable angina, active neoplasm in the past 6 months, immunosuppressive or corticosteroid therapy within the last...
- use of hallucinogens (except for cannabis), methamphetamine, or cocaine in the last 2 weeks.
The study team makes the final eligibility decision.
Where it is enrolling
- Birmingham, Alabama, United States
- Huntsville, Alabama, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 10 years to 24 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Birmingham, Alabama, United States; Huntsville, Alabama, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.