Depression study: MRI Study
Official title The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
ClinicalTrials.gov ID: NCT05453513
What this study is testing
- What it's testing
- This study is testing whether having both depression and cannabis use makes reward and pain problems worse in young people with HIV.
- Who it's for
- You may be able to join if you are a young person living with HIV who has depression and uses cannabis.
- What's involved
- You will take part in brain scans and pain tests to see how your brain reacts to rewards and pain. The study will also track your health for one year.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 59
You may be able to join if
- HIV seropositivity confirmed with lab report, medical records, or HIV testing.
- Between the ages of 18-39 years
- Fluency in English or Spanish
- Ability to provide informed consent and perform study procedures, including estimated full-scale intelligence quotient (IQ) \>75 to ensure that...
- Cannabis users: To capture a wide range of cannabis use frequency, meeting Diagnostic and Statistical Manual 5 (DSM-5) criteria for Cannabis use...
You likely can't join if
- Perinatally acquired HIV infection, as early neurodevelopmental alterations and HIV legacy effects may exist in this group
- Pregnancy or lactation
- Current Substance Use Disorder other than cannabis or nicotine
- Certified for or self-reported medical cannabis use, or intent to become certified
- Current cocaine use by self-report or urine toxicology
- central nervous system (CNS) disease or injury, or neuro-degenerative disease
See the full eligibility criteria
- HIV seropositivity confirmed with lab report, medical records, or HIV testing.
- Between the ages of 18-39 years
- Fluency in English or Spanish
- Ability to provide informed consent and perform study procedures, including estimated full-scale intelligence quotient (IQ) \>75 to ensure that participants are able to understand the study.
- Cannabis users: To capture a wide range of cannabis use frequency, meeting Diagnostic and Statistical Manual 5 (DSM-5) criteria for Cannabis use Disorder (CUD) will not be required.
- Depressed: In order to capture a wide range of depression illness severity, we will allow participants with subthreshold depression, defined as a raw severity score of ≥12 on the Montgomery Asberg Depression Rating...
- Perinatally acquired HIV infection, as early neurodevelopmental alterations and HIV legacy effects may exist in this group
- Pregnancy or lactation
- Current Substance Use Disorder other than cannabis or nicotine
- Certified for or self-reported medical cannabis use, or intent to become certified
- Current cocaine use by self-report or urine toxicology
- central nervous system (CNS) disease or injury, or neuro-degenerative disease
- Unique pain syndromes (e.g. multiple sclerosis, rheumatoid arthritis);
- Severe medical illness such as end-stage renal disease, heart failure, cirrhosis, or cancer
- At baseline, all participants will be psychotropic-medication-free for ≥1 month prior to study enrollment (or ≥3 months for medications with longer half-lives).
- Exclusionary are participants with a DSM-5 diagnoses of bipolar disorder, psychotic disorders, autism spectrum disorders, and all non-cannabis substance-related disorders will be exclusionary.
- Exclusion criteria will be the same as for non-depressed cannabis users; in addition participants will not report cannabis use in the prior 90 days and have a urine toxicology test negative for cannabis.
The study team makes the final eligibility decision.
Where it is enrolling
- Miami, Florida, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 59 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Miami, Florida, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.