Autonomic Failure study: Active CPAP
Official title CPAP for the Treatment of Supine Hypertension
ClinicalTrials.gov ID: NCT05489575
What this study is testing
- What it's testing
- This study wants to find out if using a CPAP machine can help treat high blood pressure that happens when lying down.
- Who it's for
- The study is looking for people with nerve damage that causes low blood pressure when standing and high blood pressure when lying down.
- What's involved
- Participants will spend 3 to 5 days in a research center. They will use a CPAP machine (a device that blows air through a mask) for short periods during the day and for up to 9 hours at night.
- Time commitment
- The study requires 3 to 5 days of visits to the Vanderbilt Clinical Research Center, including overnight stays.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 80
You may be able to join if
- Male and female people, age 40-80 years, with autonomic failure including pure autonomic failure, multiple system atrophy and Parkinson disease.
- Neurogenic orthostatic hypotension, defined as a ≥20-mmHg decrease in systolic blood pressure within 3 minutes of standing associated with impaired...
- Nocturnal supine hypertension (nighttime systolic blood pressure ≥140 mmHg) during the overnight screening for supine hypertension.
- Patients who are willing and able to provide informed consent
You likely can't join if
- Patients with history of recent facial trauma or surgery or intolerance to CPAP or to the CPAP mask.
- Patients who cannot tolerate the medication withdrawal, defined as those who are unable to stand for at least one minute or those with sustained...
- Bedridden patients or those who are unable to stand due to motor impairment or severe orthostatic hypotension.
- Smokers, patients who are pregnant, or have clinically unstable coronary artery disease, or major cardiovascular or neurological event in the past 6...
The study team makes the final eligibility decision.
Where it is enrolling
- Nashville, Tennessee, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Nashville, Tennessee, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.