Opioid Use Disorder study: Buspirone vs Lofexidine
Official title Evaluating Buspirone to Treat Opioid Withdrawal
ClinicalTrials.gov ID: NCT05511909
What this study is testing
What is Buspirone?
Buspirone is an investigational oral medication being studied as a potential treatment for opioid use disorder. Buspirone is designed to act as a partial agonist at serotonin 5‑HT1A receptors, which may help modulate withdrawal symptoms and cravings.
Also referred to as Buspar.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to find out if buspirone is effective in reducing symptoms of withdrawal and the urge to use opioids.
- Who it's for
- The study is looking for adults with opioid use disorder who are ready to stop using opioids.
- What's involved
- Participants will stay in a residential facility for 10 to 12 days, where they will receive a gradually reduced dose of opioids and take either buspirone or a placebo.
- Time commitment
- The study lasts 10 to 12 days and requires participants to live at the study site for the entire duration.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Aged 18-75
- Opioid positive urine sample
- Current moderate-severe opioid use disorder with evidence of physical dependence
- Interested in undergoing opioid detoxification
You likely can't join if
- Being pregnant or breastfeeding
- Enrolled in methadone or buprenorphine maintenance treatment
- Allergic to study medication or taking medications that are contraindicated with study medication (e.g., CYP3A4 inhibitors or inducers and/or...
- Significant mental health or physical disorder, or life circumstance, that is expected to interfere with study participation (detailed further in...
- Hypotension and/or prolonged QTc interval
The study team makes the final eligibility decision.
Where it is enrolling
- Baltimore, Maryland, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Baltimore, Maryland, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.