Viral Lung Infection and Acute Respiratory Failure study: Tozorakimab
Official title Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
ClinicalTrials.gov ID: NCT05624450
What this study is testing
What is Tozorakimab?
This is an investigational medicine being studied to help prevent severe breathing problems in people with viral lung infections. It is designed to block a specific protein called IL-6 that can cause inflammation in the body.
Also referred to as MEDI3506.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to find out if adding tozorakimab to standard care prevents death or the need for a breathing machine (ventilator) or heart-lung support.
- Who it's for
- The study is looking for adults who are in the hospital with a viral lung infection and need extra oxygen.
- What's involved
- Participants will receive tozorakimab along with their usual medical treatment. Doctors will monitor their health to see if they get worse or need more intensive support.
- Time commitment
- The source text does not specify the total duration of the study or the number of required visits.
- Phase 3: a large, late-stage study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult participants ≥ 18 years old at the time of signing the informed consent form.
- Patients hospitalised with viral lung infection.
- Hypoxaemia requiring treatment with supplemental O2. Hypoxaemia is defined as: SpO2 ≤ 90% OR SpO2 ≤ 92% AND one or both of the following...
You likely can't join if
- Known fungal or parasitic lung infection, aspiration lung infection, lung abscess, or evidence of septic shock.
- Hypoxaemia caused primarily by extrapulmonary insult or by lung injury of non-infective aetiology.
- Ongoing IMV/ECMO at randomisation.
The study team makes the final eligibility decision.
Where it is enrolling
- Mobile, Alabama, United States
- Tucson, Arizona, United States
- Fresno, California, United States
- Newport Beach, California, United States
- Torrance, California, United States
- Colorado Springs, Colorado, United States
- Washington D.C., District of Columbia, United States
- Gainesville, Florida, United States
- Jacksonville, Florida, United States
- Lakeland, Florida, United States
- Tampa, Florida, United States
- Boise, Idaho, United States
- Evanston, Illinois, United States
- Louisville, Kentucky, United States
- Baton Rouge, Louisiana, United States
- Annapolis, Maryland, United States
- Detroit, Michigan, United States
- Royal Oak, Michigan, United States
- Saint Paul, Minnesota, United States
- Kansas City, Missouri, United States
+ 192 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Mobile, Alabama, United States; Tucson, Arizona, United States; Fresno, California, United States; Newport Beach, California, United States; Torrance, California, United States; Colorado Springs, Colorado, United States and 206 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.