Post Traumatic Stress Disorder study: TMS-fMRI
Official title Targeting the Default Mode Network: A TMS-fMRI Study
ClinicalTrials.gov ID: NCT05646732
What this study is testing
- What it's testing
- The study aims to find out which parts of the brain change when a new type of brain stimulation is used. This information could help doctors create personalized treatments for PTSD in the future.
- Who it's for
- The study is looking for adults who have been diagnosed with Post-Traumatic Stress Disorder (PTSD).
- What's involved
- Participants will complete psychological tests and questionnaires. They will also have an initial MRI scan and two separate sessions where they receive brain stimulation while inside an MRI machine.
- Time commitment
- The total time for all visits is estimated to be five to six hours, taking place at VA Palo Alto and Stanford University.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 55
You may be able to join if
- Between 18 and 55 years of age
- Ability to maintain a Motor Threshold (MT) with single pulse TMS
- Ability to safely and comfortably undergo an MRI and TMS
- Able to read, verbalize, understand, and voluntarily sign the Informed Consent Form prior to participating in any study-specific procedures or...
- PTSD diagnosis according to the DSM 5, as determined by the Clinician administered PTSD scale (CAPS-5) criteria.
You likely can't join if
- Inability to safely and comfortably undergo an MRI. MRI safety will be determined by the center where MRI's are collected.
- Inability to safely and comfortably undergo TMS. TMS exclusions include any history or condition that puts patients at risk.
- Significant dementia as determined by the Montreal Cognitive Assessments (MoCA)
- Common comorbid disorders of Veterans are allowed, but PTSD must be a primary diagnosis causing significant impairment that could not be accounted...
- Being in urgent need of care that would make participation impossible
- Currently taking medications that increase the risk of seizure or influence hemodynamic response
See the full eligibility criteria
- Between 18 and 55 years of age
- Ability to maintain a Motor Threshold (MT) with single pulse TMS
- Ability to safely and comfortably undergo an MRI and TMS
- Able to read, verbalize, understand, and voluntarily sign the Informed Consent Form prior to participating in any study-specific procedures or assessments.
- PTSD diagnosis according to the DSM 5, as determined by the Clinician administered PTSD scale (CAPS-5) criteria.
- Commitment to maintaining a stable medication regimen between the two fMRI sessions
- Inability to safely and comfortably undergo an MRI. MRI safety will be determined by the center where MRI's are collected.
- Inability to safely and comfortably undergo TMS. TMS exclusions include any history or condition that puts patients at risk.
- Significant dementia as determined by the Montreal Cognitive Assessments (MoCA)
- Common comorbid disorders of Veterans are allowed, but PTSD must be a primary diagnosis causing significant impairment that could not be accounted for by another diagnosis.
- Being in urgent need of care that would make participation impossible
- Currently taking medications that increase the risk of seizure or influence hemodynamic response
- Presence of any other condition that has the potential to prevent study completion and/or have a confounding effect on the interpretation of results.
The study team makes the final eligibility decision.
Where it is enrolling
- Palo Alto, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 55 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Palo Alto, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.