Clinical trial for Peripheral Arterial Disease
Official title Ultrasound Cavitation Therapy for CLI
ClinicalTrials.gov ID: NCT05749250
What this study is testing
- What it's testing
- The study wants to see if ultrasound exposure to microbubble contrast agents can speed up healing of non‑healing ulcers caused by peripheral arterial disease. It also looks at changes in blood flow in the treated limb.
- Who it's for
- Adults with severe, non‑healing ulcers due to peripheral arterial disease.
- What's involved
- Participants will receive ultrasound treatment with microbubble contrast agents applied to the artery feeding the wound and to the wound itself, and will have imaging tests to measure blood flow and wound healing.
- Time commitment
- The study lasts several weeks, with multiple ultrasound sessions and follow‑up visits for imaging and wound assessment.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Known history of unilateral or bilateral PAD diagnosed by reduced ankle-brachial index (\<0.9) or non-compressible vessels
- Diagnosis of CLI (Rutherford class IV-VI), and a non-healing ischemic ulcer defined as no change in the prior 3 months.
You likely can't join if
- Major medical illness other than PAD affecting the limb (muscle disease, blood diseases that influence flow or rheology, severe heart failure [NYHA...
- Pregnant or lactating females
- Hypersensitivity to any ultrasound contrast agent or to polyethylene glycol (PEG, macrogol).
- Hemodynamic instability (hypotension with systolic BP \<90 mm Hg, need for vasopressors).
- Expected amputation or revascularization procedure within the ensuing 1 month.
The study team makes the final eligibility decision.
Where it is enrolling
- Charlottesville, Virginia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Charlottesville, Virginia, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.