Post Traumatic Stress Disorder study: Prolonged Exposure
Official title Mechanisms Underlying Efficacy of Prolonged Exposure
ClinicalTrials.gov ID: NCT05788302
What this study is testing
- What it's testing
- The study aims to see which brain, physiological, and self‑report measures predict success and change during Prolonged Exposure therapy for PTSD.
- Who it's for
- Adults diagnosed with post‑traumatic stress disorder.
- What's involved
- Participants will receive 10 weekly therapy sessions and undergo brain scans, heart‑rate tests, and questionnaires before treatment, halfway through, after treatment, and one month later.
- Time commitment
- The study lasts about three months, with weekly therapy visits and four assessment appointments.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age 18 or older
- Meeting diagnostic criteria for PTSD as defined by DSM-5 assessed by the Diagnostic Interview for Anxiety, Mood, and Obsessive-compulsive and related...
- Interest in starting PE
You likely can't join if
- Current or past history of schizophrenic or other psychotic disorders,
- Untreated Bipolar Disorder or a history of a manic/mixed episode within the last 6 months,
- Severe traumatic brain injury,
- Major neurological problems,
- Current substance use disorder of moderate or greater severity assessed by the DIAMOND,
- Active risk to self or others,
See the full eligibility criteria
- Age 18 or older
- Meeting diagnostic criteria for PTSD as defined by DSM-5 assessed by the Diagnostic Interview for Anxiety, Mood, and Obsessive-compulsive and related Psychiatric Disorders (DIAMOND), and
- Interest in starting PE
- Current or past history of schizophrenic or other psychotic disorders,
- Untreated Bipolar Disorder or a history of a manic/mixed episode within the last 6 months,
- Severe traumatic brain injury,
- Major neurological problems,
- Current substance use disorder of moderate or greater severity assessed by the DIAMOND,
- Active risk to self or others,
- Current participation in therapy other than present-centered supportive therapy,
- Previously received \> 2 sessions of Prolonged Exposure, and
- Having no memory of their traumatic event.
- For participants who are currently prescribed psychotropic medication, they will be eligible for the study provided medication use has been stable for 2 months prior to enrollment and remains stable throughout...
The study team makes the final eligibility decision.
Where it is enrolling
- Boston, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Boston, Massachusetts, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.