Clinical trial for Osteoarthritis, Knee
Official title The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty
ClinicalTrials.gov ID: NCT05800457
What this study is testing
- What it's testing
- The study will see if a synovectomy (removing the inflamed joint lining) can lower pain and improve function after knee replacement surgery.
- Who it's for
- Adults with end‑stage knee osteoarthritis who have moderate to severe joint lining inflammation seen on ultrasound.
- What's involved
- Participants will have knee replacement surgery with or without the extra step of removing the inflamed lining. They will fill out pain and function questionnaires and do physical tests before and after surgery.
- Time commitment
- The study lasts about a year, with visits before surgery and several follow‑up visits after surgery to record pain, function, and quality of life.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 41 to 80
You may be able to join if
- Males or females over the age of 40 diagnosed with knee osteoarthritis
- Scheduled for first unilateral total knee arthroplasty
- Moderate to severe (at least grade two) synovitis and synovial hyperplasia, as determined by ultrasound assessment
- Referred to the Pre-Admission Clinic at University Hospital
You likely can't join if
- Bilateral, uni-compartmental, or revision total knee arthroplasty
- Osteoarthritis due to genetic syndromes (e.g., Ehlers-Danlos Syndrome, etc.)
- Known inflammatory arthropathy, another rheumatic disease, or disease-modifying anti-rheumatic drug (DMARD) use (e.g.
- Joint injection (steroid or viscosupplement) within 12 weeks of Pre-Admission Clinic appointment date
- Cannot read, write, or understand English (printed instructions are provided in English only)
- Any factors precluding patients from attending follow-up appointments (e.g., socio-economic limitations, distance from clinic, no access to home/cell...
See the full eligibility criteria
- Males or females over the age of 40 diagnosed with knee osteoarthritis
- Scheduled for first unilateral total knee arthroplasty
- Moderate to severe (at least grade two) synovitis and synovial hyperplasia, as determined by ultrasound assessment
- Referred to the Pre-Admission Clinic at University Hospital
- Bilateral, uni-compartmental, or revision total knee arthroplasty
- Osteoarthritis due to genetic syndromes (e.g., Ehlers-Danlos Syndrome, etc.)
- Known inflammatory arthropathy, another rheumatic disease, or disease-modifying anti-rheumatic drug (DMARD) use (e.g.
- Joint injection (steroid or viscosupplement) within 12 weeks of Pre-Admission Clinic appointment date
- Cannot read, write, or understand English (printed instructions are provided in English only)
- Any factors precluding patients from attending follow-up appointments (e.g., socio-economic limitations, distance from clinic, no access to home/cell phone, etc.).
- Cognitive impairment or psychological problems that preclude the ability to understand instructions
- Not able to follow up at routine standard of care post-operative visits
The study team makes the final eligibility decision.
Where it is enrolling
- London, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 41 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at London, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.