Obstructive Sleep Apnea study: Acetazolamide
Official title Patient-centered and Neurocognitive Outcomes With Acetazolamide for Sleep Apnea
ClinicalTrials.gov ID: NCT05804084
What this study is testing
What is Acetazolamide?
an investigational oral tablet being studied as a potential treatment for obstructive sleep apnea is designed to inhibit carbonic anhydrase, causing mild diuresis and respiratory stimulation
Also referred to as Diamox.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study wants to see if acetazolamide can reduce sleep apnea severity, improve memory and quality of life, and understand how it works.
- Who it's for
- Adults who have obstructive sleep apnea and may not want or be able to use a CPAP mask
- What's involved
- Participants will take either acetazolamide or a placebo for 4 weeks, then switch to the other for another 4 weeks. After each period, doctors will measure sleep apnea severity, memory tests, and quality‑of‑life surveys.
- Time commitment
- The study lasts 8 weeks total, with two 4‑week treatment periods and assessments at the end of each period.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years
- Body mass index ≤ 35 kg/m2
- Untreated moderate/severe OSA (AHI ≥15/h)
You likely can't join if
- Substantial sleep hypoxemia (SpO2\ 10% of the monitoring time during the home sleep test, or for \>25% of the total sleep time during any of the...
- Abnormally low blood counts/electrolytes or renal function at baseline
- Use of OSA therapy during the past 1 month, or plans to urgently resume/(re)start clinical OSA therapy within 3 months
- Significant, uncontrolled cardiac, pulmonary, endocrine, renal, hepatic, neurocognitive, psychiatric, or urologic (e.g., kidney stones) disorder
- Other major sleep disorder (e.g., narcolepsy)
- Urgent need to initiate effective OSA therapy (i.e., Epworth sleepiness score \>18, commercial driver, prior sleep-related car accident, or based on...
See the full eligibility criteria
- Age ≥18 years
- Body mass index ≤ 35 kg/m2
- Untreated moderate/severe OSA (AHI ≥15/h)
- Substantial sleep hypoxemia (SpO2\ 10% of the monitoring time during the home sleep test, or for \>25% of the total sleep time during any of the in-laboratory studies)
- Abnormally low blood counts/electrolytes or renal function at baseline
- Use of OSA therapy during the past 1 month, or plans to urgently resume/(re)start clinical OSA therapy within 3 months
- Significant, uncontrolled cardiac, pulmonary, endocrine, renal, hepatic, neurocognitive, psychiatric, or urologic (e.g., kidney stones) disorder
- Other major sleep disorder (e.g., narcolepsy)
- Urgent need to initiate effective OSA therapy (i.e., Epworth sleepiness score \>18, commercial driver, prior sleep-related car accident, or based on MD judgment)
- Severe allergy to sulfa-drugs or taking another carbonic-anhydrase inhibitor (e.g., topiramate)
- Pregnancy/breastfeeding (current/planned)
- Prisoners
- Illicit substance abuse or \>2 standard drinks of alcohol/day
- Medications that may affect OSA or ventilatory control (e.g., opiates, sedatives)
- Thiazide/loop diuretic (risk of hypokalemia)
- Inability to give consent or follow procedures
- Safety concern based on MD judgment
The study team makes the final eligibility decision.
Where it is enrolling
- La Jolla, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at La Jolla, California, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.