Primary Gonarthrosis study: Triamcinolone Acetonide
Official title The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis
ClinicalTrials.gov ID: NCT05806021
What this study is testing
What is Triamcinolone Acetonide?
An investigational intra‑articular injection being studied for pain and function improvement in primary gonarthrosis (knee osteoarthritis). It is designed to reduce inflammation in the joint by suppressing inflammatory mediators.
Also referred to as Kenalog.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find out how different amounts of triamcinolone acetonide affect knee pain and ability to move.
- Who it's for
- Adults who have primary knee osteoarthritis.
- What's involved
- Participants will receive a single cortisone injection into the knee at one of three dose levels and will have follow‑up visits for pain and function checks.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 and older. Healthy volunteers may be eligible.
You may be able to join if
- Symptomatic primary gonarthrosis of over 6 months duration (gonarthrosis according to the American College of Rheumatology criteria)
- Grade 1 to 3 Kellgren-Lawrence femorotibial osteoarthritis
- Knee pain provoked by activity over 4 and under 8 on 10 (Visual Analog Scale)
You likely can't join if
- Bilateral symptomatic primary gonarthrosis
- Grade 4 Kellgren-Lawrence femorotibial osteoarthritis
- Isolated patellofemoral osteoarthritis
- Intra-articular corticosteroid infiltration to the knee within the past 3 months or chronic use of per os corticosteroid
- Intra-articular hyaluronic acid infiltration within the past 12 months.
- Intra-articular infiltration of platelet-rich plasma within the past 12 months.
See the full eligibility criteria
- Symptomatic primary gonarthrosis of over 6 months duration (gonarthrosis according to the American College of Rheumatology criteria)
- Grade 1 to 3 Kellgren-Lawrence femorotibial osteoarthritis
- Knee pain provoked by activity over 4 and under 8 on 10 (Visual Analog Scale)
- Bilateral symptomatic primary gonarthrosis
- Grade 4 Kellgren-Lawrence femorotibial osteoarthritis
- Isolated patellofemoral osteoarthritis
- Intra-articular corticosteroid infiltration to the knee within the past 3 months or chronic use of per os corticosteroid
- Intra-articular hyaluronic acid infiltration within the past 12 months.
- Intra-articular infiltration of platelet-rich plasma within the past 12 months.
- Disease affecting the study joint (systemic inflammatory disease, history of septic arthritis, osteonecrosis, etc.).
- Suspicion or presence of active local infectious process.
- Presence or suspicion of local neoplasia or metastasis
- Recent severe trauma to the knee (≤ 3 months)
- Significant cognitive impairment or inadequate language proficiency not allowing adequate response to study questionnaires
- Any other serious medical condition that does not allow participation in the study or may be a contraindication to cortisone injection
The study team makes the final eligibility decision.
Where it is enrolling
- Montreal, Quebec, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 50 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Montreal, Quebec, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.