Critical Illness study: Magnesium sulfate
Official title Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients
ClinicalTrials.gov ID: NCT05829317
What this study is testing
What is Magnesium sulfate?
This is an investigational intravenous medicine being studied to help prevent new atrial fibrillation in critically ill patients. It is designed to provide magnesium to the body, which may help stabilize heart rhythm.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether giving magnesium can prevent new‑onset atrial fibrillation in critically ill patients.
- Who it's for
- You may be able to join if you are an adult patient in the ICU and at risk for new atrial fibrillation.
- What's involved
- You would receive magnesium or a pretend treatment through an IV. Neither you nor the doctors will know which one you get.
- Time commitment
- The study lasts while you are in the ICU, with daily check‑ins.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years;
- Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24...
- Vasopressor or inotropic support with an expected duration of \>24 hours
- Cardiac arrest
- Continuous cardiac monitoring.
You likely can't join if
- Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for...
- Receiving IMV for airway protection only (for example, isolated head trauma)
- Active atrial fibrillation at the time of enrolment
- On oral or continuous infusion of Amiodarone
- Unlikely to survive \>24 hours or palliative patients
- Cardiac surgery patients
See the full eligibility criteria
- Age ≥18 years;
- Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24 hours for respiratory failure (hypercarbic or hypoxic)
- Vasopressor or inotropic support with an expected duration of \>24 hours
- Cardiac arrest
- Continuous cardiac monitoring.
- Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for \>18 hours
- Receiving IMV for airway protection only (for example, isolated head trauma)
- Active atrial fibrillation at the time of enrolment
- On oral or continuous infusion of Amiodarone
- Unlikely to survive \>24 hours or palliative patients
- Cardiac surgery patients
- Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma)
- Patients receiving dialysis
- Positive pregnancy test (females \<50 years old)
- Previously enrolled in this trial
- Treating physician refuses enrollment
The study team makes the final eligibility decision.
Where it is enrolling
- Kingston, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Kingston, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.