Clinical trial for Obesity
Official title The Effect of Time-Restricted Eating in Cardiometabolic Health
ClinicalTrials.gov ID: NCT05866406
What this study is testing
- What it's testing
- The study will see whether a 9‑hour eating window for 12 weeks changes insulin sensitivity, daily metabolism, and body tissue health, without changing weight.
- Who it's for
- Adults who are overweight or have prediabetes.
- What's involved
- Participants will follow a 9‑hour eating schedule for 12 weeks and attend clinic visits for blood tests, body scans, and other measurements.
- Time commitment
- The study lasts 12 weeks and requires several clinic visits for tests and monitoring.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 25 to 75. Healthy volunteers may be eligible.
You may be able to join if
- must be able to grant voluntary informed consent and comply with the study instructions
- aged 25-75 years
- men and women
- body mass index 27-45 kg/m2
- fasting plasma glucose 5.6-6.9 mmol/L, or 2h oral glucose tolerance test plasma glucose 7.8-11.1 mmol/L or haemoglobin A1C 39-46 mmol/mol or...
You likely can't join if
- shift worker
- fasting \>12 h/day more than once a week
- vegan
- \> once a week no food intake after \~1800 h
- habitually waking up before \~0400 h and sleeping before \~2100 h
- unstable weight (\>5% change the last 2 months)
See the full eligibility criteria
- must be able to grant voluntary informed consent and comply with the study instructions
- aged 25-75 years
- men and women
- body mass index 27-45 kg/m2
- fasting plasma glucose 5.6-6.9 mmol/L, or 2h oral glucose tolerance test plasma glucose 7.8-11.1 mmol/L or haemoglobin A1C 39-46 mmol/mol or homeostasis model assessment-insulin resistance (HOMA-IR) score ≥2.73
- self-reported habitual eating period ≥ 13 h per day
- shift worker
- fasting \>12 h/day more than once a week
- vegan
- \> once a week no food intake after \~1800 h
- habitually waking up before \~0400 h and sleeping before \~2100 h
- unstable weight (\>5% change the last 2 months)
- Clinical diagnosis of type 1 or 2 diabetes
- Clinical diagnosis of sleep disorder
- Clinical diagnosis of eating disorder
- Clinical diagnosis of cancer in last 5 years
- conditions that render subject unable to complete all testing procedures (including individuals with known allergies or contraindications to the medications used in this study)
- use of medications that affect the study outcome measures or increase the risk of study procedures and that cannot be temporarily discontinued (e.g., steroids, alpha- or beta-adrenergic blockers or agonists, etc.)
- smoking and illegal drug use
- pregnant or lactating
- gastrointestinal or bariatric surgery (except cholecystectomy and appendectomy)
- individuals with electromedical devises
- prisoners
- alcohol abuse
The study team makes the final eligibility decision.
Where it is enrolling
- Cambridge, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 25 years to 75 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Cambridge, United Kingdom. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.