Chest Pain study: Outpatient Evaluation vs Hospitalization Evaluation
Official title CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain)
ClinicalTrials.gov ID: NCT05897632
What this study is testing
- What it's testing
- The study wants to see whether a rapid outpatient evaluation is as safe and effective as hospital admission for patients with moderate‑risk acute chest pain, while also looking at patient experience and use of resources.
- Who it's for
- Adults who come to the emergency department with acute chest pain and are judged to be at moderate risk for a heart attack.
- What's involved
- After giving consent, participants are randomly assigned to either go home for a fast outpatient assessment or stay in the hospital for standard care. They will receive the assigned tests and follow‑up as part of the study.
- Time commitment
- The study follows participants through their initial evaluation, which may involve a short outpatient visit or a brief hospital stay.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 and older
You may be able to join if
- Age ≥21 years old
- Chest pain or Symptoms of acute coronary syndrome (ACS)
- Moderate risk of ACS (all of the below)
- Hear Score 4-6
- Non-Ischemic electrocardiogram (ECG)
You likely can't join if
- ST Elevation Myocardial Infarction (STEMI) Activation
- ST Changes or new T-wave inversions ≥1mm on ECG
- Any Elevated Troponin Measure (Based on Sex-Specific 99th Percentile)
- Serial change between Troponin Measures (Delta) ≥5 pg/mL
- Stress Echocardiography, Nuclear Stress Test, Stress ECG, Stress Cardiac MRI, Coronary CT Angiogram (CCTA), Invasive Coronary Angiography (Cardiac...
- "Clean" CCTA or Cardiac Cath (0% stenosis in all vessels) within the past 2 years
See the full eligibility criteria
- Age ≥21 years old
- Chest pain or Symptoms of acute coronary syndrome (ACS)
- Moderate risk of ACS (all of the below)
- Hear Score 4-6
- Non-Ischemic electrocardiogram (ECG)
- Two Troponin measures \< Sex-Specific Upper Reference Limit
- Women \<15 pg/ml
- Men \<20 pg/ml
- No prior coronary artery disease (CAD)
- No Prior Myocardial Infarction (MI)
- No Prior Coronary Revascularization Procedures
- No Patients with ≥ 70% Obstructive Coronary Disease
- ST Elevation Myocardial Infarction (STEMI) Activation
- ST Changes or new T-wave inversions ≥1mm on ECG
- Any Elevated Troponin Measure (Based on Sex-Specific 99th Percentile)
- Serial change between Troponin Measures (Delta) ≥5 pg/mL
- Stress Echocardiography, Nuclear Stress Test, Stress ECG, Stress Cardiac MRI, Coronary CT Angiogram (CCTA), Invasive Coronary Angiography (Cardiac Cath) within 1 year
- "Clean" CCTA or Cardiac Cath (0% stenosis in all vessels) within the past 2 years
- Chest Trauma
- Pregnancy
- Life Expectancy \< 1 year
- Other comorbid conditions requiring hospitalization
- Unstable Vitals (Blood Pressure \ 120 or \<50, O2 Sat \<90%)
- End Stage Renal Disease; Dialysis or estimated glomerular filtration rate (eGFR) \<30 mL/min
- Transfers From Another Hospital
- Non-English Speaking
- Prisoners
- Prior Enrollment
- Already Enrolled in Other treatment Trial
The study team makes the final eligibility decision.
Where it is enrolling
- Detroit, Michigan, United States
- Charlotte, North Carolina, United States
- Winston-Salem, North Carolina, United States
Compensation & support
A stipend or payment for your time may be offered.
No amount is published here because ClinicalTrials.gov has no reliable field for payment or travel support. Ask the study team what's actually covered (payment for your time, travel, parking, or other study costs), and never join a trial for the compensation alone.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team, so confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Detroit, Michigan, United States; Charlotte, North Carolina, United States; Winston-Salem, North Carolina, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.