Clinical trial for ALS
Official title Combined Respiratory Training in Persons With ALS
ClinicalTrials.gov ID: NCT05913882
What this study is testing
- What it's testing
- The study wants to find out if combining lung volume recruitment and expiratory muscle training improves cough strength, breathing ability, and how patients feel about shortness of breath and swallowing. It also looks at how the program affects patients’ and caregivers’ quality of life.
- Who it's for
- It is looking for people who have been diagnosed with ALS and have breathing or swallowing difficulties.
- What's involved
- Participants will do specific breathing exercises that involve pulling air into the lungs and strengthening the muscles that help exhale. They will also have tests to measure cough strength and breathing function, and will fill out questionnaires about their symptoms and quality of life.
- Time commitment
- The study will involve up to 39 patients and will last for a period that includes several visits for exercise sessions and assessments, but the exact length is not specified in the source.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 90
You may be able to join if
- A diagnosis of probable or definite ALS in accordance with the Revisited El-Escorial Criteria.
- Disease duration from symptom onset of ≤ 2 years,
- Lung volume recruitment and expiratory muscle strength training naïve,
- Reduced peak cough flow (% predicted for age and gender).
You likely can't join if
- History of stroke, head and neck cancer or other concomitant disorder that might contribute to dysphagia or respiratory impairment.
- Use of prescription cough assist or non-invasive volume ventilation devices.
- Enrollment in another research investigation that might impact cough or respiratory function.
- Diagnosis of frontotemporal dementia or advanced cognitive impairment.
- Tracheostomy placement/Use of invasive mechanical ventilation.
- Contraindications for respiratory training (i.e., history of pneumothorax, severe chronic obstructive pulmonary disease).
The study team makes the final eligibility decision.
Where it is enrolling
- Fort Lauderdale, Florida, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 90 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Fort Lauderdale, Florida, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.