Head and Neck Squamous Cell Carcinoma study: MRI
Official title HN-QUEST: A Study of Head and Neck Imaging Biomarkers
ClinicalTrials.gov ID: NCT05919290
What this study is testing
- What it's testing
- This study is testing whether weekly MRI scans can help doctors change radiation plans during treatment. It also looks at how MRI images can predict how well the treatment works.
- Who it's for
- You may be able to join if you have newly diagnosed head and neck cancer and are getting radiation therapy, or if you are a healthy volunteer for the MRI part.
- What's involved
- You would get MRI scans during your treatment. In the first group you might have up to one scan each week. In the second group you would have scans before treatment, in week 2, week 4, and a few weeks after treatment ends. Healthy volunteers would have two scans at different times.
- Time commitment
- The study lasts about 6 to 8 weeks of treatment plus a few weeks after. You will need to come in for several MRI scans during that time.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Age \>/= 18 years
- Histologically proven Head and Neck Squamous Cell carcinoma
- Primary or nodal disease \> 3cm for biomarker imaging
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
- Planned for curative surgery or (chemo)radiotherapy
You likely can't join if
- As judged by investigator evidence of systemic disease that makes unsuitable for study
- Contra-indication for serial MRI scans
- Previous solid tumor treated within last 5 years
- Pregnancy
- History of significant obstructive airway disease
- History of gadolinium contrast allergy Inclusion Criteria for Healthy Volunteers
See the full eligibility criteria
- Age \>/= 18 years
- Histologically proven Head and Neck Squamous Cell carcinoma
- Primary or nodal disease \> 3cm for biomarker imaging
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
- Planned for curative surgery or (chemo)radiotherapy
- Willingness to undergo repeat MRI
- Able to receive and understand verbal and written information regarding study and able to give written informed consent
- Adequate renal function: Calculated creatinine clearance \>/= 30ml/min
- Be able to lie comfortably on back for 1 hour
- As judged by investigator evidence of systemic disease that makes unsuitable for study
- Contra-indication for serial MRI scans
- Previous solid tumor treated within last 5 years
- Pregnancy
- History of significant obstructive airway disease
- History of gadolinium contrast allergy Inclusion Criteria for Healthy Volunteers
- Age \>/= 18 years
- Able to receive and understand verbal and written information regarding study and able to give written informed consent
- Willingness to undergo repeat MRI Exclusion Criteria for Healthy Volunteers
- Unwillingness to sign informed consent
- Contra-indication for MRI
- Underlying significant respiratory disease
The study team makes the final eligibility decision.
Where it is enrolling
- Toronto, Ontario, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Toronto, Ontario, Canada. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.