Major Depressive Disorder study: ALTO-300
Official title Study of ALTO-300 in MDD
ClinicalTrials.gov ID: NCT05922878
What this study is testing
What is ALTO-300?
ALTO-300 is an investigational capsule being studied as a potential treatment for Major Depressive Disorder.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study is testing whether ALTO-300 works better than a pretend treatment. It looks at how well it helps people with major depression.
- Who it's for
- You may be able to join if you have major depression and are taking other medicine for it.
- What's involved
- You would take ALTO-300 or a pretend treatment. You would keep taking your regular antidepressant medicine.
- Time commitment
- The source text does not say how long the study lasts or what visits are needed.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Have a diagnosis of moderate to severe major depressive disorder (MDD)
- At Visit 1, currently taking a stable dose of 1 or 2 antidepressants (e.g., SSRI, SNRI, bupropion, or gepirone) for at least 6 weeks with no dose...
- Willing to comply with all study assessments and procedures
- Must not be pregnant or breastfeeding at time of enrollment or throughout study
You likely can't join if
- Evidence of unstable medical condition
- Nightly use of sleep medication
- Diagnosed bipolar disorder, psychotic disorder, or dementia
- Current moderate or severe substance use disorder
- Has a history of hypersensitivity or allergic reaction to ALTO-300 or any of its components/excipients
- Concurrent or recent participation in another clinical trial for mental illness involving an investigational product or device
The study team makes the final eligibility decision.
Where it is enrolling
- Phoenix, Arizona, United States
- Rogers, Arkansas, United States
- Bellflower, California, United States
- Lafayette, California, United States
- Mather, California, United States
- Moorpark, California, United States
- Temecula, California, United States
- Denver, Colorado, United States
- Tampa, Florida, United States
- Fayetteville, Georgia, United States
- Boise, Idaho, United States
- Worcester, Massachusetts, United States
- Mankato, Minnesota, United States
- Minneapolis, Minnesota, United States
- St Louis, Missouri, United States
- Las Vegas, Nevada, United States
- Albuquerque, New Mexico, United States
- New York, New York, United States
- Rose Hill, North Carolina, United States
- Winston-Salem, North Carolina, United States
+ 8 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Phoenix, Arizona, United States; Rogers, Arkansas, United States; Bellflower, California, United States; Lafayette, California, United States; Mather, California, United States; Moorpark, California, United States and 22 more locations. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.