Prevention trial for Osteoarthritis, Knee
Official title The Osteoarthritis Prevention Study
ClinicalTrials.gov ID: NCT05946044
What this study is testing
- What it's testing
- The study compares a weight‑loss and exercise program to a control group to see if it stops knee osteoarthritis from developing, and also looks at pain, mobility, quality of life, joint forces, inflammation, weight loss, confidence in exercise, and cost.
- Who it's for
- Women aged 50 or older who are obese and have little or no knee pain.
- What's involved
- Participants will follow a diet and exercise plan and keep their weight down, while the control group receives general health information. They will have visits, tests, and MRI scans to track knee health.
- Time commitment
- The program lasts about 12 months, with regular clinic visits and MRI scans to monitor progress.
Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 50 and older, women only. Healthy volunteers may be eligible.
You may be able to join if
- Female
- BMI ≥ 30 kg/m2
- An eligible knee will have no OA by xray and MRI
- No or infrequent knee pain (\< 15 days/month) in the same knee
You likely can't join if
- symptomatic or severe coronary artery disease
- unable to walk without a device
- blindness
- type 1 diabetes
- active treatment for cancer
- during the past 12 months knee fracture, anterior cruciate ligament (ACL), medial collateral ligament (MCL), or meniscus injury with or without...
See the full eligibility criteria
- Female
- BMI ≥ 30 kg/m2
- An eligible knee will have no OA by xray and MRI
- No or infrequent knee pain (\< 15 days/month) in the same knee
- symptomatic or severe coronary artery disease
- unable to walk without a device
- blindness
- type 1 diabetes
- active treatment for cancer
- during the past 12 months knee fracture, anterior cruciate ligament (ACL), medial collateral ligament (MCL), or meniscus injury with or without surgical repair
- knee injection during the past 6 months
- bilateral knee OA by x-ray Kellgren-Lawrence (KL) ≥ 2
- bilateral knee OA by MRI
- bilateral symptomatic knee OA (frequent bilateral knee pain \> 15 days per month)
- BMI\< 30.0 kg/m2
- male sex
- claustrophobia
- contraindication to MRI including body weight \> 300 lbs or knee coil does not fit
- unwillingness or inability to change eating and physical activity habits due to environment
- cannot speak and read English
- planning to leave area \> 2 months during the 48-month intervention period
The study team makes the final eligibility decision.
Where it is enrolling
- Boston, Massachusetts, United States
- Winston-Salem, North Carolina, United States
- Sydney, Australia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 50 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Boston, Massachusetts, United States; Winston-Salem, North Carolina, United States; Sydney, Australia. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.