Clinical trial for Alcohol-Related Carcinoma
Official title Role of Acetaldehyde in the Development of Oral Cancer
ClinicalTrials.gov ID: NCT05973656
What this study is testing
What is Alcohol?
An investigational oral dose of alcohol being studied as a potential factor in alcohol-related carcinoma research.
Also referred to as Ethanol, ethyl alcohol.
Plain-language explanation of the investigational treatment. It is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The study aims to find out how a chemical produced by the body after drinking alcohol affects cells in the mouth.
- Who it's for
- The study is looking for healthy volunteers and people with a genetic condition called Fanconi anemia.
- What's involved
- Participants will drink a single dose of alcohol and provide samples of saliva, mouth cells, and urine. They may also give two small blood samples.
- Time commitment
- The study involves one visit where samples are collected at different times after drinking.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 45. Healthy volunteers may be eligible.
You may be able to join if
- 21-45 years of age for alcohol drinkers
- Occasionally consume alcohol
- At least 1 drink per month for healthy volunteers
- At least 1 drink in the last 3 months for Fanconi anemia patients
- Meets one of the three criteria
You likely can't join if
- Pregnant or nursing
- Taking any medication or drug that might affect alcohol use and absorption or that might be affected by alcohol consumption
- Healthy volunteers who have taken any antibiotics in the last 3 months
- Currently consuming more than 21 drinks per week
- Have any history of alcohol or drug related problems
- Current or former tobacco/nicotine product(s) user
See the full eligibility criteria
- 21-45 years of age for alcohol drinkers
- Occasionally consume alcohol
- At least 1 drink per month for healthy volunteers
- At least 1 drink in the last 3 months for Fanconi anemia patients
- Meets one of the three criteria
- Healthy volunteer - ALDH2\ 1/1\ homozygotes-not of Eastern Asian decent;
- Healthy volunteer - ALDH2\ 1/2\ heterozygotes-of Eastern Asian decent and experience flushing when drinking
- Individual's with Fanconi anemia (FA).
- 18-45 years of age for non-drinkers
- Never consume alcohol/not had alcohol in the last 6 months
- Healthy volunteers.
- Non-smoker (smoked \< 100 cigarettes in a lifetime)
- Pregnant or nursing
- Taking any medication or drug that might affect alcohol use and absorption or that might be affected by alcohol consumption
- Healthy volunteers who have taken any antibiotics in the last 3 months
- Currently consuming more than 21 drinks per week
- Have any history of alcohol or drug related problems
- Current or former tobacco/nicotine product(s) user
- Any regular use of tobacco/nicotine products or marijuana in the last year (cigarettes, e-cigarettes, cigars, pipes, smokeless tobacco)
- "Trying" or limited use of any nicotine products or marijuana in the last 1 month
- Active infection (influenza, cold, COVID, respiratory / sinus infection) - admission in the study will be delayed pending improved health
- Non-FA volunteers who have an unstable medical condition or condition that could be affected by alcohol consumption (insulin-dependent diabetes, ulcers, heart issues)
- Experience severe adverse events (nausea, blacking out) when consuming even low doses of alcohol
The study team makes the final eligibility decision.
Where it is enrolling
- Minneapolis, Minnesota, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part, but confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 45 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
This study is enrolling now at Minneapolis, Minnesota, United States. Enter your location above to see the nearest enrolling site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool that is independent of the study sponsor. Details come from ClinicalTrials.gov. The study team decides eligibility, and your own doctor gives medical advice.